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  • Particle Characterization: Challenges Associated With Submicrometer-Sized Objects

    Wednesday, April 02, 2014
    Application Note
    Craig S. Schwandt
    Materials in the form of particulate or engineered objects are relatively easy to characterize in terms of their composition, shape, size, and size distribution, provided they are larger than 1 µm in... read more

  • Electronic Pipetting: The Call for Innovation

    Thursday, February 27, 2014
    Application Note
    Paula Heimler
    Take a close look around most laboratories and you will find an old, barely used fixture. No one knows who ordered it or who it belongs to. It is yellowed, dusty, and top heavy, with a small keyboard ... read more

  • Integrating Microscopy Into the Analytical Scheme: A Pittcon® 2014 Microscopy Review

    Monday, February 24, 2014
    Technical Article
    Barbara Foster
    Microscopy is often overlooked at Pittcon®, yet of the 12,000+ scientists who attend, approximately 30% use microscopy in some form (according to ongoing research from The Microscopy & Imaging Place, ... read more

  • Bioassays and Bioanalytical Method Development 2013

    Tuesday, November 12, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Biotherapeutics are generally large molecules with a heterogeneous complex structure that is directly related to their ability to modulate biological reactions. This precludes defining a meaningful ... read more

  • Improved Long-Term Culture Using A Microfluidic Platform

    Monday, October 07, 2013
    Application Note
    Alex Mok Paul Hung Cindy Chen Sónia Gil Kathleen Ongena
    Precise and biologically relevant in vitro studies require the ability to analyze cell responses to perturbations over time. In order to achieve successful long-term cell culture and imaging, however,... read more

  • Multiparameter Pluripotency Analysis Using Magnetic Bead Assays

    Wednesday, August 28, 2013
    Application Note
    Nikolai Stankiewicz Thomas Siegl Frederick Wiese
    For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ... read more

  • Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays

    Friday, June 07, 2013
    Application Note
    Amedeo Cappione Masaharu Mabuchi David Briggs Timothy Nadler
    Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-... read more

  • Product Intelligence: Stereomicroscope Technology

    Tuesday, May 28, 2013
    Technical Article
    Katriona Scoffin
    Stereomicroscopes find application in many areas of science, such as pharmaceutical, environmental, forensics, and foods. A common use of the stereomicroscope is to magnify biological samples. This ... read more

  • Putting the “More” in Morphology: Part 1

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Segmentation, the ability to define the unique features in a region of interest, has always been the greatest challenge in image analysis and quantitation. A new suite of tools, available from ... read more

  • Putting the “More” in Morphology: Part 2

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Part 1 of this article discussed the impact of multiplexing morphological methods, multiparametric techniques, and supervised machine-learning to answer the question "what" is there, as well as "where... read more

  • A High-Resolution Look at Glass Delamination Using Transmission Electron Microscopy (TEM)

    Tuesday, April 09, 2013
    Technical Article
    Elaine F. Schumacher
    Formation of glass delamination flakes and secondary products through reaction of injectable pharmaceutical solutions with glass vial packaging leads to product contamination and costly recalls. ... read more

  • Use of an Environmental Transmission Electron Microscope for Dynamic in situ Studies of Nano-...

    Thursday, March 07, 2013
    Application Note
    Joerg R. Jinschek
    Current research and development (R&D) that is focused on efficient energy conversion and environmental protection technologies relies heavily on advances in the development of new and improved ... read more

  • Microscopy + Spectroscopy: Pittcon® 2013 Celebrates the Power of Two

    Thursday, March 07, 2013
    Technical Article
    Barbara Foster
    The year 2013 celebrates a new benchmark for imaging at Pittcon®. Historically, Pittcon has not been considered an imaging meeting, despite the fact that a review of Pittcon 2012 statistics revealed ... read more

  • An Ultrasensitive Immunoassay Detection System for Biomarkers Utilizing Raman Scattering Methods

    Wednesday, October 31, 2012
    Technical Article
    Samar Kundu Charles Ginsburgh Sandra Lynch Neal Siegel
    Detection of low levels of biomarkers utilizing enzyme linked immunosorbent assay (ELISA) technology is demonstrated through the use of Raman scattering techniques and a convertible substrate for ... read more

  • Product Intelligence: Buyers' Guide to Biological Confocal Microscopes

    Thursday, May 24, 2012
    Technical Article
    T. Keith Brock
    Confocal microscopes offer the user a number of important advantages, including high resolution, ability to electronically adjust magnification, and improved signal-to-noise ratios. In addition, the ... read more

  • Microscopy: Imaging Broader, Diving Deeper

    Monday, April 09, 2012
    Technical Article
    Barbara Foster
    In previous articles and editorials, the life sciences have been defined as the “next big growth area” in microscopy, spectroscopy, and related imaging techniques. read more

  • New Solutions for Surface Texture Analysis

    Monday, November 01, 2010
    Technical Article
    Barbara Foster
    Most microscopists are familiar with confocal microscopy from neuroscience or cell biology. However, very quietly and abruptly, confocal has jumped the fence into industry, becoming a major tool-of-... read more

  • Confidence Up Close

    Friday, January 01, 2010
    Application Note
    Aubrey Lambert
    The combined pressures of continuing miniaturization, higher packing densities, and rigorous quality assurance means that the physical size of particles capable of adversely affecting industrial ... read more

  • Multicapillary Columns for Chromatography

    Tuesday, March 01, 2005
    Technical Article
    Yuri P. Belov Marina M. Ulyanova Vladimir N. Sidelnikov
    The principles and theory of high-speed capillary chromatography have been known since the 1960s. To realize the maximum speed capabilities, it is necessary to use capillaries with a diameter of ... read more

  • Rapid Testing of Toxic Chemicals

    Tuesday, March 01, 2005
    Application Note
    Nathalie Boucher Lucie Lorrain Marie-Eve Rouette Elisabeth Perron Nancy Déziel Louis Tessier François Bellemare
    The measurement of chlorophyll fluorescent signals from photosynthetic enzyme complexes (PEC) has becomeone of the most powerful indicators for ecophysiologists. read more
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