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  • Urinary Drug Testing: Small Changes for Big Improvements in Sensitivity

    Tuesday, September 27, 2016
    Application Note
    Jenny Cybulski
    An oversight or mistake in drug testing can have dire consequences—a positive drug test can ruin the possibility of employment, turn an accident into a lawsuit, or cause a physician to discontinue ... read more

  • Automated Chromatographic Solid-Phase Extraction Using an Autosampler

    Thursday, September 01, 2016
    Application Note
    Mark Hayward Jonathan Ho Rick Youngblood Matthew T. Hardison Tom Moran Kim Gamble
    Solid-phase extraction (SPE) is a preferred tool for isolating target analytes from complex matrices because the availability of a diverse range of chromatographic sorbents enables targeted approaches... read more

  • Ion-Exchange Selectivity and High-Resolution Accurate-Mass Spectrometry Elucidate Lithium-Ion ...

    Monday, May 09, 2016
    Application Note
    Christopher Pohl Charanjit Saini Rosanne W. Slingsby Paul J. Voelker Kate Comstock John Moote Michael P. Balogh Ramona Y. Ying
    Improved performance and lifetime of lithium-ion batteries is important for automobile manufacturers that produce cars powered electrochemically by lithium-ion battery packs. read more

  • Quantitative Analysis of H2A.X and ATM DNA Damage Signals Using Benchtop Flow Cytometry

    Friday, September 25, 2015
    Application Note
    Mark Santos Wenying Zhang
    Assessing the level of DNA damage present in cells is integral to understanding the molecular mechanisms involved in the genome repair process and consequences for cell fate. read more

  • Evaluation of an Automated Solid-Phase Extraction Method Using Positive Pressure

    Wednesday, April 08, 2015
    Application Note
    Heidi Fleischer Kerstin Thurow Ellen Vorberg Carolin Gallert Thomas Roddelkopf Steffen Junginger
    Investigations for the determination of drugs in real samples, while gaining in importance, are limited by time and sample throughput. In response to this, the authors developed an automated solid-... read more

  • Application of Porous Nano-Calcium Titanate in Preconcentration of Heavy Metals in Water

    Wednesday, October 15, 2014
    Application Note
    Dong Zhang Yan Li
    Heavy metal pollution in water has been a public concern for decades.Heavy metals, which include lead, cadmium, mercury, chromium, zinc, copper, and nickel, are highly toxic with hidden pollution, ... read more

  • How Solid-Phase Extraction Affects Challenges in Bioanalysis

    Wednesday, February 05, 2014
    Application Note
    Mike Oliver Tim Liddicoat Ken Meadows
    Modern bioanalytical laboratories are tasked with providing high-quality analytical results from complex biological samples in a high-throughput environment. These needs have to be balanced with the ... read more

  • Pittcon 2013®: Developments in Liquid Chromatography

    Monday, May 13, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The first commercial liquid chromatograph was probably an amino acid analyzer. These ion exchange chromatographs were so specialized that they had almost no impact on chemical analysis outside of ... read more

  • Sample Prep for LC, GC, and SFC at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    At Pittcon® 2013, sample prep stood out as a major focus, perhaps because of the few advances in chromatography instrumentation. In addition, some sample preparation is spilling over into other ... read more

  • Product Intelligence: Solid Phase Extraction Systems

    Monday, February 25, 2013
    Technical Article
    Solid phase extraction, or SPE, is used to isolate pollutants in water and pesticides in food, isolate drugs in blood and tissue samples, and separate proteins from a mixture, among other applications... read more

  • Automated Botulinum Neurotoxin Detection

    Monday, February 25, 2013
    Technical Article
    Karine Bagramyan Aneela Reddy Dobrin Nedelkov Markus Kalkum
    Botulinum neurotoxin (BoNT) is undoubtedly the most potent biological toxin known. Intravenously injected it could paralyze and kill a human being at a dose of just 1.2 ng BoNT per kg body weight. read more

  • Analyzing Volatile Organic Chemicals in Food: Emerging Trends and Recent Examples

    Thursday, February 14, 2013
    Technical Article
    David Barden
    The detection of volatile organic compounds (VOCs) is important for a variety of reasons, many of which stem either from the need to ensure that damaging chemicals are controlled or eliminated, or the... read more

  • Focus on Liquid Handling and 3-D Imaging at SLAS 2013

    Friday, February 08, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Most commonly, laboratory automation involves a few hundred wells run for a specific purpose. SLAS 2013, the meeting of the Society for Laboratory Automation and Screening, was held at the Gaylord ... read more

  • Second-Generation Expanded Bed Adsorption Scales from Lab to Plant

    Thursday, January 17, 2013
    Application Note
    Robert L. Stevenson, Ph.D.
    Expanded bed adsorption (EBA) was introduced in 1999 with adsorbents that were used for pressure-driven packed beds. These had densities in the range of 1.1–1.5 g/mL, which was not much higher than ... read more

  • Reducing DNA Sample Backlogs and Protecting Chain-of-Custody in the Forensic Laboratory

    Monday, December 24, 2012
    Technical Article
    Laurent Baron Bobby Chavli Lois Tack Annette Summers
    For years, forensic laboratories in the U.S. have struggled to reduce DNA sample processing backlogs and human errors, both of which hinder timely and reliable criminal convictions. read more

  • Optimizing HPLC Sample Preparation

    Monday, February 06, 2012
    Technical Article
    Caitlin Smith
    Sample preparation is an important component for analysis in high-performance liquid chromatography (HPLC)/ultra high-performance liquid chromatography (UHPLC). This article outlines commonly used ... read more

  • Effect of PBS Solutions on Chemokine Secretion of Human Peripheral Blood Mononuclear Cells

    Friday, January 28, 2011
    Technical Article
    Michael Lichtenauer Stefanie Nickl Konrad Hoetzenecker Andreas Mangold Andreas Mitterbauer Stefan Hacker Matthias Zimmermann Hendrik Jan Ankersmit
    Phosphate-buffered saline (PBS), a buffer solution commonly used in many biological research fields, contains monobasic potassium phosphate, sodium chloride, and dibasic sodium phosphate. read more

  • Multicapillary Columns for Chromatography

    Tuesday, March 01, 2005
    Technical Article
    Yuri P. Belov Marina M. Ulyanova Vladimir N. Sidelnikov
    The principles and theory of high-speed capillary chromatography have been known since the 1960s. To realize the maximum speed capabilities, it is necessary to use capillaries with a diameter of ... read more

  • Rapid Testing of Toxic Chemicals

    Tuesday, March 01, 2005
    Application Note
    Nathalie Boucher Lucie Lorrain Marie-Eve Rouette Elisabeth Perron Nancy Déziel Louis Tessier François Bellemare
    The measurement of chlorophyll fluorescent signals from photosynthetic enzyme complexes (PEC) has becomeone of the most powerful indicators for ecophysiologists. read more

  • Miniaturized FTIR for Maximized Productivity

    Tuesday, March 01, 2005
    Application Note
    Ken Fredeen John S. Seelenbinder Mark L. Norman
    In today’s fast-paced business environment, many companies are under pressure to improve their productivity. This is especially true in the pharmaceutical industry, where reducing time-to-market ... read more
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