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Vaccine Storage: Keeping Vaccines Safe When They Are In Highest Demand
Friday, January 04, 2013
Alex Esmon
Flu season is upon us and laboratories are doing their part to make sure vaccines are prepared and ready for distribution. One of the biggest problems faced by laboratories and clinics during flu ...
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Understanding Concentration and Evaporation and Technology: Part 1: Basic Principles of Commonly Used Evaporation Techniques
Wednesday, February 06, 2013
Induka Abeysena
Rob Darrington
Solvent removal is an essential process across a broad range of applications in the pharmaceutical, chemical, and biotechnology industries. Although a diversity of sample formats and solvents are used...
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Understanding Concentration and Evaporation Technology: Part 2: Latest Developments in System Technology
Tuesday, February 26, 2013
Induka Abeysena
Rob Darrington
An understanding of the evaporative process and factors affecting it, involving careful selection of a vacuum pump, cold trap or condenser, and consideration of pressure control, is key to obtaining a...
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Detection of siRNA-Mediated Gene Modulation Using RNA Detection Probes
Monday, May 20, 2013
Don Weldon
Grace Johnston
To study the function of genes and biological pathways, researchers often use techniques such as RNA interference (RNAi) to modify gene expression. In RNAi experiments, it is important to determine ...
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Point-of-Care Tests for Anemia
Wednesday, May 22, 2013
The presence of anemia, which is the insufficient oxygen-carrying capacity of the blood, can be determined by the total hemoglobin concentration. This lab test is the most commonly ordered in hospital...
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The Streck HbA1c-Cellular® Control: Intact Red Blood Cells for Hemoglobin A1c Testing
Thursday, May 23, 2013
Glycated hemoglobin A, or HbA1c, testing is the most effective means of monitoring diabetes mellitus and determining how well the disease is being controlled. HbA1c testing can now be used to diagnose...
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Point-of-Care Tests for the Blood Lipid Profile
Wednesday, August 28, 2013
Blood lipid levels must be assessed to monitor for risk of cardiovascular disease, or CVD. The most critical lipids for risk determination are cholesterol, low-density lipoprotein (LDL), high-density ...
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Choosing Conservation Over Conversion: The Great Helium Debate
Thursday, May 23, 2013
Frank Kandl
Reginald Bartram
In recent months, the growing shortage of helium has gained national attention and raised concerns of availability and cost among users. Laboratories in particular rely on helium for analytical ...
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Automation in the Drug Discovery Process: Delivering Analytical Chemistry to Biologists and Beyond
Friday, March 08, 2013
Wendy Gaisford
Over the past decade, advances in genomic- and proteomic-based research techniques and instrumentation have resulted in major breakthroughs in the elucidation of the structure and function of disease ...
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Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays
Friday, June 07, 2013
Amedeo Cappione
Masaharu Mabuchi
David Briggs
Timothy Nadler
Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-...
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Spectroscopic Ellipsometry Characterization of Thin Films Used in the Food Packaging Industry
Tuesday, June 11, 2013
Michelle N. Sestak
Process control and optimization is critical for low-cost, high-throughput, thin-film applications, such as barrier layers used in the food packaging industry. One useful technique for determining ...
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The Cytochrome P450 System and Patient-Specific Pharmacotherapy
Wednesday, June 19, 2013
A portion of the more than 50 Cytochrome P450, or CYP450, enzymes are quite important from a clinical standpoint. This article looks at the role of CYP450 enzymes in drug–drug interactions and ...
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A Novel Sensor for Uric Acid Based on an Electropolymerization Technique
Tuesday, July 02, 2013
Youyuan Peng
A molecularly imprinted polymer (MIP) film was fabricated using an electropolymerization technique after depositing carboxyl-functionalized multiwalled carbon nanotubes (MWNTs) onto a glassy carbon ...
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High-Throughput Screening of Multiple Protein Complexes
Thursday, July 04, 2013
Imre Berger
Maxime Chaillet
Frederic Garzoni
Sinyee Yau-Rose
Barney Zoro
Key protein complexes are fundamental to a wide range of cellular processes and key metabolic pathways within the body. Their dysfunction is associated with a range of disease pathologies such as ...
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Measurement of IL-6 RNA Levels in Live Cells
Wednesday, July 10, 2013
Shobana Vaidyanathan
Infections and tissue damage lead to acute inflammatory responses, orchestrated by the release of cytokines from macrophages and mast cells, as well as endothelium and tumor cells. Tumor necrosis ...
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Direct Improvement With Direct Dilution
Friday, August 09, 2013
Joe Olechno
Sean Ekins
Antony J. Williams
Mark Fischer-Colbrie
The advent of a new technology often brings far-reaching benefits well beyond the initial perception of its key advantages. Acoustic dispensing, for example, with the ability to have highly ...
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Dynamic Light Scattering (DLS) Microrheology: Taking Rheological Characterization to Extremes
Thursday, August 29, 2013
Steve Carrington
Microrheology is a relatively new and developing analytical methodology of growing interest to those working at the forefront of rheological characterization. The term “microrheology” is used to ...
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Multiparameter Pluripotency Analysis Using Magnetic Bead Assays
Wednesday, August 28, 2013
Nikolai Stankiewicz
Thomas Siegl
Frederick Wiese
For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ...
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Impact of New Pipetting Techniques on Safety in the Laboratory
Monday, September 02, 2013
Bobby Chavli
Annette Summers
Mary Napier
According to the Occupational Safety and Health Administration (OSHA), on average, it takes between 18 and 36 months to develop and implement a new regulation, trailing the pace of science. As a ...
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Characterizing Nanoparticles in Liquids: Protein Aggregation Studies
Monday, September 16, 2013
Pauline Carnell
Sarah Newell
Many patients’ lives have been improved with the use of monoclonal antibodies and recombinant proteins since their commercialization about 30 years ago. Work in the field of therapeutic proteins ...
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