Technical Articles

This month’s installment is the third in a series of real-world examples of calibration diagnostics. read more

The past seven articles have provided the fundamentals of calibration, including a protocol for designing a calibration study. read more

In the last installment in this series, it was suggested that a rule-of-thumb for calibration designs was five-by-five (i.e., five replicates of each of five concentrations), for a total of 25 data ... read more

Calibration is a modeling procedure by which a response (e.g., peak area) can be transformed into a useful measurement (e.g.,concentration). read more

Welcome to “Statistics in analytical chemistry.” read more

Examples of early drug approvals illustrate the power of mass spectrometry-based approaches. read more

This article explains the different pipets available and modes of operation. Important considerations when looking for a pipet include ergonomic factors, such as hand position and the amount of force ... read more

Aided by recent advances in medical technology, researchers are developing ways to use biomarkers to identify the likelihood of a wide range of disorders. read more

In the last column we discussed the use of pooling to get a better estimate of the standard deviation of the measurement method, essentially the standard deviation of the raw data. read more

A true story: one of my former graduate students called me and said, in effect, “Help. I know I’m a good analytical chemist, but my company is making me look like a perfect analytical chemist.” read more