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The Story of MALS
Saturday, October 05, 2013
Philip J. Wyatt
The concept of measuring light scattered from a solution at each of a plurality of angles simultaneously began in late 1976 in a very unlikely application. At that time, scientists from Science ... read more
HPLC 2012: New Mysteries in Column Efficiency
Monday, October 01, 2012
Robert L. Stevenson, Ph.D.
HPLC is the premier meeting series for liquid chromatographers to gather to learn about the latest advances in technology and applications. read more
Scientific Imaging: To Sharpen or Obscure?
Monday, October 01, 2012
Jerry Sedgewick
In the world of scientific imaging, the matter of whether or not to sharpen an image can pose an ethical question: Does sharpening change the essential nature of the image? read more
Point-of-Care Diagnostics for the Third World
Monday, October 01, 2012
Robert L. Stevenson, Ph.D.
The Gates Foundation provides extensive funding for programs to improve health care for the poor with a special emphasis on resource-constrained or third-world countries. read more
Product Intelligence: Potentiometric and Karl Fischer Titrators
Monday, September 10, 2012
Caitlin Smith
The potentiometric titrator and the Karl Fischer titrator are highlighted in this buyers’ guide to titrators. When choosing a KF titrator, the user should determine what types of solvents and samples ... read more
Product Intelligence: Guide to Purchasing a Rotary or Nitrogen Evaporator
Monday, September 10, 2012
T. Keith Brock
In addition to the research laboratory, lab evaporators find application across the chemical, pharmaceutical, petrochemical, and food industries. This article provides an overview of two evaporator ... read more
Simultaneous Determination of Neutral and Anionic Analytes With a Single Column: Method Development Examples Using a Reversed-Phase/Weak Anion Exchange Mixed-Mode Column
Saturday, October 01, 2011
Xu Qun Chen Jing Jeffrey Rohrer
Many samples contain not only neutral hydrophobic analytes, commonly determined using reversed-phase (RP) HPLC, but ionic analytes. read more
Chromatographic Behavior of Activated Alumina Adsorbents for the Analysis of Hydrocarbons
Saturday, October 01, 2011
Jaap de Zeeuw Bill Bromps Tom Vezza Rick Morehead
Alumina porous layer open tubular (PLOT) columns have long been used for the analysis of volatile hydrocarbons. read more
Light-Emitting Diodes: A New Solution for Fluorescence
Saturday, October 01, 2011
Barbara Foster
From the dramatic increase in new fluorophores to the proliferation of techniques like total internal reflection fluorescence (TIRF), photoactivated localization microscopy (PALM), and stochastic... read more
Use of Integrated Data Analysis to Gain an Advantage in Biomarker Discovery and Personalized Medicine
Saturday, October 01, 2011
Jens Hoefkens
The genomic revolution of the last two decades has provided pharmaceutical companies with an almost overwhelming number of potential drug targets. read more
Statistics in Analytical Chemistry: Part 44—R²
Saturday, October 01, 2011
David Coleman Lynn Vanatta
Imagine that a new method has been developed and now needs a calibration curve. read more
Use of qPCR to Detect Biomarkers for Assessing Stem Cells
Saturday, October 01, 2011
Jaime Sabel
In the human body, undifferentiated stem cells are the raw material used to repopulate tissues and organs in response to accidental cell death or normal cell turnover. read more
Can Technology Crack and Extract Useful Knowledge From Proteomics, or is the Proteome too Complex?
Saturday, October 01, 2011
Robert L. Stevenson, Ph.D.
Society has invested tens of billions of dollars in the last two decades to sequence the human genome and look for biomarkers to fight disease and guide therapy. read more
Using MALS-UV-RI Detection for Accurate Characterization of PEGylated Proteins
Saturday, October 01, 2011
Michelle Chen
PEGylation involves covalent attachment of synthetic polyethylene glycol (PEG) chains to another molecule, usually a protein, peptide, or nucleotide. read more
Specifying a Water Purification System for the Laboratory
Thursday, November 07, 2013
Steve Mines
The selection, operation, and maintenance of a reverse osmosis (RO) water purification system should be straightforward. However, systems are often 1) inaccurately specified, i.e., not matched to the... read more
Precision Medicine Will Digitize Humans, But Who Pays?
Thursday, November 07, 2013
Robert L. Stevenson, Ph.D.
In a serendipitous confluence of events, I was finishing the 2013 edition of Eric Topol’s book, "The Creative Destruction of Medicine: How the Digital Revolution will Create Better Health Care," ... read more
Product Intelligence: CO2 Incubators: Keeping Cultured Cells Healthy
Thursday, October 24, 2013
Caitlin Smith
A CO2 incubator is crucial for growing and maintaining cultured cells. CO2 incubators can be water-jacketed, in which the layer around the incubator has heated water, or air-jacketed, also known as ... read more
Product Intelligence: Differential Scanning Calorimetry—A Fundamental Thermal Analysis Tool
Friday, October 25, 2013
Josh P. Roberts
Differential scanning calorimeters (DSCs) are valuable tools that are used to determine the heat capacity and thermodynamic transition of a wide variety of samples. DSCs are employed in many areas, ... read more
Overcoming the Challenges of Polymerase Chain Reaction
Wednesday, October 17, 2012
Jeffrey M. Perkel
Multiplex PCR finds application in such areas as pathogen detection, forensics, gene expression analysis, and SNP genotyping. While the technique is both sensitive and economical and enhances ... read more
An Ultrasensitive Immunoassay Detection System for Biomarkers Utilizing Raman Scattering Methods
Wednesday, October 31, 2012
Samar Kundu Charles Ginsburgh Sandra Lynch Neal Siegel
Detection of low levels of biomarkers utilizing enzyme linked immunosorbent assay (ELISA) technology is demonstrated through the use of Raman scattering techniques and a convertible substrate for ... read more