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Analytical Method Execution Automation: PAT for Pharmaceutical QC Laboratory Operations
Friday, March 25, 2005
John P. Helfrich
With the FDA’s increasing focus on modernizing regulation of pharmaceutical manufacturing and product quality, companies are being forced to reexamine whether traditional development and ... read more
LC-MS With Simultaneous Electrospray and Atmospheric Pressure Chemical Ionization
Tuesday, March 01, 2005
Wayne P. Duncan Patrick D. Perkins
Today, liquid chromatography-mass spectrometry with electrospray ionization (LC-ESI-MS) is increasingly being used as the technique of choice for high-throughput pharmaceutical analysis. read more
Use of Microcoil Probes to Acquire More Sensitive NMR Spectral Data
Tuesday, February 01, 2005
Peter Froehlich
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique that is commonly used to provide structural information as well as other chemical metrics such as sample composition ... read more
Statistics in Analytical Chemistry: Part 15—Calibration Example 5
Tuesday, February 01, 2005
David Coleman Lynn Vanatta
This real-world example of calibration diagnostics involves the ion-chromatographic behavior of phosphoric acid; phosphate is the actual analyte form that is measured by the instrument. read more
Statistics in Analytical Chemistry: Part 19—Internal Standards
Thursday, December 01, 2005
David Coleman Lynn Vanatta
The previous several articles have dealt with calibrationstudy design and calibration-diagnostic procedures. read more
A Versatile Column for Surfactant Analysis by HPLC
Friday, November 25, 2005
Xiaodong Liu Chris Pohl
Surfactants are widely used for industrial, agricultural, and pharmaceutical applications, in products as diverse as pesticides, detergent powders, petroleum products, cosmetics,and pharmaceuticals. read more
Focus on Microscopy: Spectroscopy + Microscopy + . . .? What’s Next?
Tuesday, November 01, 2005
Barbara Foster
Thomas Friedman, author of the recent book, The World is Flat, identified convergence of technologies as a key driving force shaping today’s world. read more
A Zoom Fluorescence Research Microscope for Macro- to Microfluorescence Imaging
Friday, November 25, 2005
Christopher Higgins
Scientists are increasingly interested in viewing both ends of the research spectrum—from cellular and subcellular level observations to tissue,organ, and whole animal studies. read more
Statistics in Analytical Chemistry: Part 18—Calibration Example 6 (Concluded)
Thursday, September 01, 2005
David Coleman Lynn Vanatta
In the previous article (American Laboratory Aug 2005), borate data were presented. No single model was found to be adequate. read more
Statistics in Analytical Chemistry: Part 17—Calibration Example 6
Monday, August 01, 2005
David Coleman Lynn Vanatta
This installment will present the sixth and last in this series of calibration examples. read more
Methodologies for Stabilization of Pharmaceuticals in Biological Samples
Friday, July 01, 2005
Jiwen Chen Ganfeng Wang Jean-Marc Brisson Yunsheng Hsieh
The instability of small drug molecules in biological fluids causes serious bioanalytical challenges, regardless of what type of powerful analytical technology is employed for the bioanalytical ... read more
Capillary-Channeled Polymer (C-CP) Fibers: A Novel Platform for Liquid-Phase Separations
Wednesday, June 01, 2005
Dwella M. Nelson Rayman D. Stanelle Phil Brown R. Kenneth Marcus
In spite of its relative maturity as a group of analytical methods, the field of liquid chromatography continues to evolve with regard to the development of new stationary phases that may provide ... read more
Using FAIMS to Increase Selectivity for LC-MS Analyses
Wednesday, June 01, 2005
Roger Guevremont Beata Kolakowski
In the development of many LC-MS methods, interferences are commonplace. In an environment in which data must stand up to rigorous scrutiny, such as in the pharmaceutical industry, selectivity of ... read more
Focus on Microscopy: AFM’s New Nanotomography Expands 3-D Imaging
Sunday, May 01, 2005
Barbara Foster
Atomic force microscopy (AFM) is well known for its ability to image and measure surface properties. read more
Statistics in Analytical Chemistry: Part 16—Calibration Example 5 (Concluded)
Sunday, May 01, 2005
David Coleman Lynn Vanatta
In the previous article (American Laboratory, Feb 2005), calibration data were diagnosed for a study involving phosphate. read more
$Developing a Laser Diffraction Particle Size Analyzer for Current Customer Requirements$
Developing a Laser Diffraction Particle Size Analyzer for Current Customer Requirements
Saturday, January 01, 2005
Duncan Griffiths
Particle size analysis has traditionally been dominated by historical techniques such as sieving or sedimentation procedures. read more
Statistics in Analytical Chemistry: Part 11—Calibration Example
Friday, May 14, 2004
David Coleman Lynn Vanatta
This article is the first in a series of real-world calibration analyses. read more
Statistics in Analytical Chemistry: Part 10—Calibration Diagnostics (concluded)
Monday, March 01, 2004
David Coleman Lynn Vanatta
This month's article will conclude the three-part series explaining calibration diagnostics. read more
Statistics in Analytical Chemistry: Part 9—Calibration Diagnostics (continued)
Monday, February 02, 2004
David Coleman Lynn Vanatta
The previous article (American Laboratory, Nov 2003) introduced the subject of calibration diagnostics. read more
Statistics in Analytical Chemistry: Part 14—Calibration Example 4
Friday, December 17, 2004
David Coleman Lynn Vanatta
This fourth real-world example of calibration diagnostics comes from the same study as did Part 13 (American Laboratory, Sept 2004). read more