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  • Analytical Method Development in the Quality by Design Framework

    Tuesday, December 16, 2014
    Application Note
    Torgny Fornstedt Dennis Åsberg Jörgen Samuelsson Anders Karlsson Krzysztof Kaczmarski
    The development of analytical methods in the Quality by Design (QbD) framework is currently gaining great momentum in the pharmaceutical industry. Presented here is a case study in which a ... read more

  • Direct Improvement With Direct Dilution

    Friday, August 09, 2013
    Application Note
    Joe Olechno Sean Ekins Antony J. Williams Mark Fischer-Colbrie
    The advent of a new technology often brings far-reaching benefits well beyond the initial perception of its key advantages. Acoustic dispensing, for example, with the ability to have highly ... read more

  • R&D Informatics at Molecular Med Tri-Con 2013

    Tuesday, February 26, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Integrated R&D Informatics and Knowledge Management (I&KM) was the title of one of the 15 programs spread over three days at the 20th Molecular Med Tri-Con held February 13–15 at the Moscone Center in... read more

  • Light-Emitting Diodes: A New Solution for Fluorescence

    Saturday, October 01, 2011
    Technical Article
    Barbara Foster
    From the dramatic increase in new fluorophores to the proliferation of techniques like total internal reflection fluorescence (TIRF), photoactivated localization microscopy (PALM), and stochastic... read more

  • Drying of Problematic Purification Samples by Lyophilization in a Centrifugal Evaporator

    Monday, June 13, 2011
    Application Note
    Induka Abeysena Rob Darrington
    Lyophilization is often the preferred method of sample drying because a high level of dryness is achieved with low residual solvent levels, and because of the light, powdery, “fluffy” finish of the ... read more

  • Microscopy in 2011: The Imaging Suite is the Microscope

    Thursday, April 07, 2011
    Application Note
    Scott Jordan
    In the 1980s, Sun Microsystems coined the trademark “The Network is the Computer” to herald the days of distributed computing. read more

  • Are You Attracted to Science? Attend Pittcon®—The Magnet for Scientific Innovation

    Tuesday, February 01, 2011
    Technical Article
    Penny. R Gardner
    We are very excited for Pittcon® 2011 to be back in Atlanta, GA, March 13–18, at the Georgia World Congress Center. read more

  • Absorption and Emission Red Shift in Stained Cell and Tissue Samples

    Monday, May 05, 2008
    Technical Article
    Eugene Barash Pavel A. Fomitchov Robert Filkins Mark Mayers Anup Sood Radislav A. Potyrailo Hua Xia Michael Montalto
    The design of fluorescence microscopes and selection of dyes are better served by the knowledge of environmental effects on dyes, whether they are in vitro or in vivo. read more

  • The LED Light Source: A Major Advance in Fluorescence Microscopy

    Wednesday, October 10, 2007
    Technical Article
    Becky Hohman
    Fluorescence microscopy requires an intense light source at the specific wavelength that will excite fluorescent dyes and proteins. read more

  • Increased Throughput in Method 8270 Analysis

    Monday, January 01, 2007
    Application Note
    William D. Goodman Frank DeLorenzo
    Method 8270 is a GC-MS method created by the U.S. EPA Office of Solid Waste for the analysis of semivolatile organics by gas chromatography-mass spectrometry. read more

  • Automated Chemical Ionization in GC-MS

    Monday, January 01, 2007
    Application Note
    Chris Sandy Jean-Francois Garnier Bernhard Rothweiler Fred Feyerherm Sihem Ben Mahmoud Harry F. Prest
    Gas chromatography with mass spectrometric detection using chemical ionization (CI) has demonstrated great utility in a wide variety of application areas ranging from forensics to environmental to ... read more

  • Microscopy is Moving On

    Friday, July 01, 2005
    Technical Article
    Aubrey Lambert
    The basis for observations has not really changed in all the time that lenses have been used to magnify objects. read more

  • Miniaturized FTIR for Maximized Productivity

    Tuesday, March 01, 2005
    Application Note
    Ken Fredeen John S. Seelenbinder Mark L. Norman
    In today’s fast-paced business environment, many companies are under pressure to improve their productivity. This is especially true in the pharmaceutical industry, where reducing time-to-market ... read more
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