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  • Thin-Layer Chromatography/Mass Spectrometry Analysis of Sample Mixtures Using a Compact Mass ...

    Tuesday, May 12, 2015
    Application Note
    Changtong Hao Nigel Sousou Daniel Eikel Jack Henion
    Thin-layer chromatography (TLC) is a planar chromatographic technique used to separate the components of a mixture by employing a thin stationary phase supported by an inert backing. It can be ... read more

  • High-Throughput Tools for Optimizing Drug Nanosuspensions

    Thursday, February 19, 2015
    Application Note
    Dennis H. Leung Timothy Rhodes Annette Bak
    Inadequate absorption and bioavailability often make it difficult to deliver the drug to the target in vivo and pose significant challenges to the discovery and development of new drugs. A number of ... read more

  • Thorough Risk Assessment Supports At-Scale Process Safety

    Wednesday, July 16, 2014
    Application Note
    Urs Groth
    It goes without saying that in any manufacturing environment no one sets out to design an unsafe process. However, it is not enough to ensure a process will be safe under normal operating conditions. read more

  • Determination of Total Mercury Content and Trace Metal Analysis in Wood Materials—Part 1: ICP-OES ...

    Tuesday, August 06, 2013
    Application Note
    Heidi Fleischer Kerstin Thurow
    The transition metal mercury has many exciting properties; for example, it is the only known metal that is liquid at room temperature, hence its use in thermometers. Other common applications are in ... read more

  • R&D Informatics at Molecular Med Tri-Con 2013

    Tuesday, February 26, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Integrated R&D Informatics and Knowledge Management (I&KM) was the title of one of the 15 programs spread over three days at the 20th Molecular Med Tri-Con held February 13–15 at the Moscone Center in... read more

  • Connecting the Dots With a Foundation for Biological Registration

    Tuesday, August 02, 2011
    Technical Article
    Frank Brown John Conway
    The last decade has seen huge advances in biological research. The advent of genomics and proteomics,as well as experimental approaches such as next-generation sequencing and high-throughput screening... read more

  • A UV Shadowing Technique Using a CCD Imaging System

    Monday, April 04, 2011
    Application Note
    Lindsey Bunn Afaf El-Sagheer
    To visualize DNA and RNA on a gel requires the use of a dye or a radiolabel. read more

  • A Multifrequency Temperature-Modulated Technique For DSC

    Sunday, January 01, 2006
    Application Note
    Markus Schubnell Christoph Heitz Thomas Hütter Steven Sauerbrunn Juergen E.K. Schawe
    In conventional differential scanning calorimetry (DSC), a sample is subjected to a temperature program with a constant heating rate. As a result, the DSC instrument delivers an output signal, which, ... read more

  • A High-Sensitivity Sensor for DSC

    Friday, August 05, 2005
    Application Note
    Rudolf Riesen Blaine Weddle
    A dramatic increase in sensitivity at low signal noise without a significant loss in signal resolution has been achieved with the HSS7 high-sensitivity sensor. read more

  • Multicapillary Columns for Chromatography

    Tuesday, March 01, 2005
    Technical Article
    Yuri P. Belov Marina M. Ulyanova Vladimir N. Sidelnikov
    The principles and theory of high-speed capillary chromatography have been known since the 1960s. To realize the maximum speed capabilities, it is necessary to use capillaries with a diameter of ... read more

  • Rapid Testing of Toxic Chemicals

    Tuesday, March 01, 2005
    Application Note
    Nathalie Boucher Lucie Lorrain Marie-Eve Rouette Elisabeth Perron Nancy Déziel Louis Tessier François Bellemare
    The measurement of chlorophyll fluorescent signals from photosynthetic enzyme complexes (PEC) has becomeone of the most powerful indicators for ecophysiologists. read more

  • Miniaturized FTIR for Maximized Productivity

    Tuesday, March 01, 2005
    Application Note
    Ken Fredeen John S. Seelenbinder Mark L. Norman
    In today’s fast-paced business environment, many companies are under pressure to improve their productivity. This is especially true in the pharmaceutical industry, where reducing time-to-market ... read more

  • LC-MS With Simultaneous Electrospray and Atmospheric Pressure Chemical Ionization

    Tuesday, March 01, 2005
    Technical Article
    Wayne P. Duncan Patrick D. Perkins
    Today, liquid chromatography-mass spectrometry with electrospray ionization (LC-ESI-MS) is increasingly being used as the technique of choice for high-throughput pharmaceutical analysis. read more
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