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Title
The Importance of Monodisperse Silica in the Evolution of UHPLC and HPLC Column Performance
Tuesday, March 10, 2015
Richard A. Henry
Paul Ross
William R. Betz
Gaurang Parmar
Wayne K. Way
There is growing interest in the use of monodisperse particle-size distribution or PSD (here defined as having 10% RSD or less) to prepare modern HPLC columns because good correlation has been ...
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Best Practices When Changing From HPLC to TOC Analysis for Cleaning Validation
Thursday, January 18, 2018
Lukas Swanson
Cleaning process/sample compatibility, cleaning limit acceptance criteria, and product recovery/solubility should be considered when investigating the feasibility of TOC analysis for CV.
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A Real-Time Concentration Monitor for Flowing Streams
Wednesday, July 26, 2017
Gary W. Yanik
Necmi Bugdayci
Soydan Kavraal
A real-time concentration monitor will improve the benefits of continuous processing and analysis by reducing or eliminating the need for sample extractions and off-line analyses.
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Automated Nephelometric Turbidity Measurement of Biotherapeutics Formulations
Friday, September 29, 2017
Daniel Kinder
With accurate turbidity data, the Freeslate biologics formulation workstation provides rapid sample preparation and analysis to support drug discovery and development activities.
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Optimized High-Throughput Compound Sample Management With An Acoustic Liquid Handling Platform
Monday, January 01, 2018
Isabella Broderick-Forster
Implementing a system centered around acoustic liquid handling helps bring the latest technology innovations to drug discovery and positively impacts all facets of sample management.
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Analysis of Benzene at Fence Lines Using GC/PID
Thursday, January 18, 2018
Jack Driscoll
Jennifer Maclachlan
This article describes methods of preparing standards, materials used, and performance of a handheld portable gas chromatograph with a photoionization detector (GC/PID) for the analysis of ppb levels ...
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Analytical Technology on the Frontline of the War on Synthetic Cannabinoids
Friday, November 10, 2017
Dominic Andrada
Advances in LC/MS technology and cloud-based systems provide and new level of efficiency in forensics labs.
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Testing and Troubleshooting Liquid Chromatography Method Transfer
Friday, November 10, 2017
Paula Hong
Jinchuan Yang
Mark Benvenuti
Gareth Cleland
Patricia McConville
Factors that affect method transfer are discussed, particularly as they relate to the analysis of isoflavones in soy extract.
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Impact of Weighing Accuracy and Data Integrity in Forensic Drug Analysis
Friday, November 10, 2017
Tucker Rubino
Klaus Fritsch
Thomas Rohrer
To stay compliant with ever-changing regulations and withstand any challenge in court, it is critical for managers and scientists in forensic laboratories to be well-informed about the key issues ...
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Isothermal Titration Calorimetry: An Indispensable Tool for Biological Pathway Research and Drug Development
Monday, October 02, 2017
Verna Frasca
As our knowledge of the genetic and molecular basis of disease continues to grow, drug development programs focus increasingly on those proteins associated with disease states.
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ASTM-Approved Method for Simultaneous Determination of Total Nitrogen and Phosphorus in Wastewater by Ion Chromatography
Monday, October 02, 2017
Jeff Rohrer
Richard Jack
Brian De Borba
As natural elements in aquatic ecosystems, nitrogen and phosphorus support the growth of algae and aquatic plants, providing food and shelter for fish and other organisms.
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Failure Analysis of Rubber Materials Using Pyrolysis-GC/MS
Wednesday, February 14, 2018
Rojin Belganeh
William Pipkin
Pyrolysis GC/MS has a wide variety of applications for identifying the organic composition of unknown samples by providing detail information about the compounds present in a sample.
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Innovations in Metals Analysis Optimize the Process
Thursday, January 18, 2018
David Smith
From reagent addition to sample digestion, faster, and safer metals digestion can be achieved with the latest technology.
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Centrifugal Partition Chromatography: The Key to Green Preparative Chromatography
Monday, March 26, 2018
Gregoire Audo
Centrifugal partition chromatography is a sustainable solution for reducing the environmental impact of preparative chromatography while reducing production costs.
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Routine Maintenance in ICP-MS: Critical When Monitoring Elemental Impurities in Pharmaceuticals
Tuesday, May 01, 2018
Robert Thomas
Routine maintenance is critical in ICP-MS, and this article provides guidance on keeping the sample introduction clean.
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Minimizing Contamination in Cell Culture Laboratories
Tuesday, March 27, 2018
Mary Kay Bates
Cell culture laboratories share the requirement for equipment and consumables that help to reduce contamination, protecting sample integrity for downstream use.
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High-Throughput Capillary Electrophoresis: The Key to Streamlined Quality Analysis for Next-Gen Sequencing
Tuesday, May 01, 2018
Steve Siembieda
The introduction of automated, high-throughput capillary electrophoresis instruments has made it possible to streamline the analysis of next-generation sequencing libraries.
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A Blood Separation Device That Eliminates Centrifugation and Reduces Preanalytical Errors and Turnaround Times
Friday, February 09, 2018
Darren Lee
Clinical diagnostic testing laboratories are under increased pressure to continually provide accurate results for each patient tested while reducing turnaround times (TATs).
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Statistics in the Laboratory: The Limit of Quantitation
Thursday, January 18, 2018
Stanley N. Deming
In the two previous columns, we discussed the limit of detection LD, the minimum signal strength above which we can state with at least a given level of confidence (e.g., =99.95%) that analyte is ...
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Advances in Single-Cell Biology Using Mass Spectrometry
Wednesday, March 22, 2017
Rohan Thakur
Single-cell analysis by MS has proven extremely valuable in discovering unique neuropeptides in a broad range of animal models, from complex mammalian species to simpler organisms such as sea slugs.
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