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  • Sample Processing at Pittcon® 2014

    Tuesday, May 06, 2014
    Application Note
    Robert L. Stevenson, Ph.D.
    The tenfold increase in speed for the analytics (GC, HPLC, and SFC [supercritical fluid chromatography], all with MS) over the last decade has shifted the choke point in many workflows from analytics ... read more

  • How Solid-Phase Extraction Affects Challenges in Bioanalysis

    Wednesday, February 05, 2014
    Application Note
    Mike Oliver Tim Liddicoat Ken Meadows
    Modern bioanalytical laboratories are tasked with providing high-quality analytical results from complex biological samples in a high-throughput environment. These needs have to be balanced with the ... read more

  • Product Intelligence: Solid Phase Extraction Systems

    Monday, February 25, 2013
    Technical Article
    Solid phase extraction, or SPE, is used to isolate pollutants in water and pesticides in food, isolate drugs in blood and tissue samples, and separate proteins from a mixture, among other applications... read more

  • Optimizing HPLC Sample Preparation

    Monday, February 06, 2012
    Technical Article
    Caitlin Smith
    Sample preparation is an important component for analysis in high-performance liquid chromatography (HPLC)/ultra high-performance liquid chromatography (UHPLC). This article outlines commonly used ... read more

  • Matrix Degradation Assays for Investigating Cell Invasion

    Tuesday, November 01, 2011
    Application Note
    Jun Ma Luke Armstrong Janet Anderl
    Tumor metastasis, inflammation, and development are accompanied by the invasion of cells through the extracellular matrix. read more

  • The State of Microscopy for 2012

    Tuesday, November 01, 2011
    Technical Article
    Barbara Foster
    In various recent interviews, I’ve been asked about the state of microscopy and, most specifically, the rise of technologies such as AFM (atomic force microscopy) and Raman confocal and the ... read more

  • Ensuring the Purity of Acetonitrile During Quality Control Testing

    Monday, March 01, 2010
    Technical Article
    Steven F. Eaton
    Acetonitrile is a critical solvent for a number of important technologies. Its low viscosity and low chemical reactivity make it a popular choice as a mobile phase for liquid chromatography. It also ... read more

  • Ultrafast Flow Liquid Chromatography of Proteins

    Monday, March 01, 2010
    Technical Article
    Kert Ivie
    Ultrahigh-pressure liquid chromatography (UHPLC) has been applied successfully to separations of many small molecules, including peptides. Few studies have involved proteins, and these were narrowly ... read more

  • Capillary UHPLC Coupled with MRM-MS for Quantitative, High-Sensitivity Bioanalysis

    Monday, March 01, 2010
    Technical Article
    Kerry Nugent Lori Ann Upton Yixin Zhu Chris Loran
    Over the past 20 years, liquid chromatography-multiple reaction monitoring-mass spectrometry (LC-MRM-MS) has become the primary tool for the bioanalysis of drugs and their metabolites in physiological... read more

  • Routine Implementation of Very-High-Pressure Liquid Chromatography in Pharmaceutical Development

    Monday, March 01, 2010
    Technical Article
    Qinggang Wang Brent Kleintop
    High-pressure liquid chromatography is probably the most widely used analytical technique for characterizing drug substances and drug products in the pharmaceutical industry. It is widely employed ... read more
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