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  • Improving the Crystallization Process for Optimal  Drug Development

    Improving the Crystallization Process for Optimal Drug Development

    Friday, March 28, 2014
    Application Note
    Michael Collazo, Soheila Vaezeslami, Sarah Burl
    Macromolecular X-ray crystallography is an important and powerful technique in drug discovery. Studying the specific interactions of a particular drug with its protein target at the atomic level can ... read more
  • Electronic Pipetting: The Call for Innovation

    Electronic Pipetting: The Call for Innovation

    Thursday, February 27, 2014
    Application Note
    Paula Heimler
    Take a close look around most laboratories and you will find an old, barely used fixture. No one knows who ordered it or who it belongs to. It is yellowed, dusty, and top heavy, with a small keyboard ... read more
  • Bioassays and Bioanalytical Method Development 2013

    Bioassays and Bioanalytical Method Development 2013

    Tuesday, November 12, 2013
    Technical Article
    Robert L. Stevenson
    Biotherapeutics are generally large molecules with a heterogeneous complex structure that is directly related to their ability to modulate biological reactions. This precludes defining a meaningful ... read more
  • Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays

    Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays

    Friday, June 07, 2013
    Application Note
    Amedeo Cappione, Masaharu Mabuchi, David Briggs, Timothy Nadler
    Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-... read more
  • What’s New in Optical Spectroscopy at Pittcon® 2013?

    What’s New in Optical Spectroscopy at Pittcon® 2013?

    Friday, May 10, 2013
    Technical Article
    Mark Fisher
    Soon after the first spectrophotometer was built, the challenge of improving it began. How could we make spectrophotometers better? Could we make them smaller, faster, or perhaps improve the ... read more
  • Putting the “More” in Morphology: Part 1

    Putting the “More” in Morphology: Part 1

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Segmentation, the ability to define the unique features in a region of interest, has always been the greatest challenge in image analysis and quantitation. A new suite of tools, available from ... read more
  • Recent Developments in Sulfur Analysis

    Recent Developments in Sulfur Analysis

    Thursday, January 17, 2013
    Application Note
    Scott Fess
    Environmental concerns to limit and minimize sulfur in crude oil and petroleum fuels are continuing to spread to many regions of the world, requiring new standard test methods and modern ... read more
  • Neutron Crystallography Contributes to Drug Design

    Neutron Crystallography Contributes to Drug Design

    Monday, January 07, 2013
    Technical Article
    Zoe Fisher
    Carbonic anhydrases are a large group of enzymes that are expressed in humans. Carbonic anhydrase (CA) catalyzes the reversible hydration of CO2 to make bicarbonate and a proton. As such, this enzyme ... read more
  • An Ultrasensitive Immunoassay Detection System for Biomarkers Utilizing Raman Scattering Methods

    An Ultrasensitive Immunoassay Detection System for Biomarkers Utilizing Raman Scattering Methods

    Wednesday, October 31, 2012
    Technical Article
    Samar Kundu, Charles Ginsburgh, Sandra Lynch, Neal Siegel
    Detection of low levels of biomarkers utilizing enzyme linked immunosorbent assay (ELISA) technology is demonstrated through the use of Raman scattering techniques and a convertible substrate for ... read more
  • Pittcon® 2012 Roundup of Spectroscopy and Mass Spectrometry

    Pittcon® 2012 Roundup of Spectroscopy and Mass Spectrometry

    Monday, May 07, 2012
    Technical Article
    Jeffrey M. Perkel
    This past March, some 15,754 people from 90 countries descended on Orlando, Florida, for the annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Pittcon®). read more
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