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  • The Future of DNA Synthesis

    Thursday, May 26, 2016
    Application Note
    Devin Leake
    Since the launch of the Human Genome Project, the genomes of over 180 organisms have been sequenced. read more

  • Long-Range Sequencing is Required to Unlock the Full Genome

    Friday, February 19, 2016
    Application Note
    Michael Schnall-Levin
    Next-generation sequencing (NGS) provides unprecedented access to one of biology’s greatest mysteries—the genome. read more

  • Long Reads and the Return of Reference Genomes

    Thursday, February 18, 2016
    Application Note
    Chris Boles Jonas Korlach
    The availability of inexpensive, massively parallel short-read sequencers shifted the focus of high-quality reference genome production to resequencing and draft genome assemblies, emphasizing ... read more

  • Reference Standards Address Technical Challenges in DNA Resequencing

    Tuesday, August 04, 2015
    Application Note
    Natalie A. LaFranzo
    The extensive workflow required to analyze DNA samples using next-generation sequencing (NGS) leaves many opportunities for the introduction of variability. read more

  • Next-Generation Sequencing for Disease Biomarkers

    Monday, December 15, 2014
    Application Note
    Darren Lee
    Next-generation sequencing (NGS) is beginning to provide powerful insights into genetic mutations and molecular networks underlying disease for a broad set of genes. NGS technologies promise to ... read more

  • Protein Aggregation at PepTalk 2014

    Monday, March 31, 2014
    Technical Article
    Robert L. Stevenson, Ph.D.
    Quantitative analysis of subvisible particles is an important unsolved problem, as discussed in the Particle Analysis track of PepTalk 2014, held January 12–17 at the Renaissance Hotel and Palm ... read more

  • Bioassays and Bioanalytical Method Development 2013

    Tuesday, November 12, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Biotherapeutics are generally large molecules with a heterogeneous complex structure that is directly related to their ability to modulate biological reactions. This precludes defining a meaningful ... read more

  • DNA in Forensics

    Wednesday, August 28, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The proliferation of forensic DNA testing and databases by state and local jurisdictions was recently reported by Joseph Goldstein in The New York Times. For years, the FBI’s combined indexing system ... read more

  • Direct Improvement With Direct Dilution

    Friday, August 09, 2013
    Application Note
    Joe Olechno Sean Ekins Antony J. Williams Mark Fischer-Colbrie
    The advent of a new technology often brings far-reaching benefits well beyond the initial perception of its key advantages. Acoustic dispensing, for example, with the ability to have highly ... read more

  • A Capillary Gel Electrophoresis Fluorescence System for Antibody–Antigen Interactions

    Wednesday, August 07, 2013
    Application Note
    Shou-Kuan Tsai Ming-Jhy Hseu Varoujan D. Amirkhanian
    Since its inception more than 20 years ago, slab gel-based electrophoresis technology has been used routinely for the analysis of biomolecules (i.e., DNA, proteins, and carbohydrates). However, use of... read more

  • The Role of Synthetic DNA in Big DNA and Genetics Research

    Friday, August 02, 2013
    Technical Article
    Dan Gibson Hans Packer
    Synthetic biology is defined as the de novo design and construction of biological devices and systems, and as such is heavily reliant on the use of synthetic DNA. The size and sequence of potential ... read more

  • Pittcon 2013®: Developments in Liquid Chromatography

    Monday, May 13, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The first commercial liquid chromatograph was probably an amino acid analyzer. These ion exchange chromatographs were so specialized that they had almost no impact on chemical analysis outside of ... read more

  • Advances in Gas Chromatography Instrumentation at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The buzzwords for Pittcon® 2013 in gas chromatography instrumentation were “smaller,” “portable,” and “helium.” Despite the fact that some of the major vendors did not exhibit, others were on hand ... read more

  • What’s New in Optical Spectroscopy at Pittcon® 2013?

    Friday, May 10, 2013
    Technical Article
    Mark Fisher
    Soon after the first spectrophotometer was built, the challenge of improving it began. How could we make spectrophotometers better? Could we make them smaller, faster, or perhaps improve the ... read more

  • Advances in Mass Spectrometry at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Brian Musselman
    This has been a busy year for mass spectrometry companies and with the Triennial International Conference on Mass Spectrometry occurring last fall. This year at Pittcon®, several new high-end mass ... read more

  • Exhibition of Chromatography Columns at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The technology and market for liquid chromatography columns continue to mature, with applications-specific columns on the rise. The chromatography columns target specific assays in the clinical ... read more

  • Awarding Innovation: The Pittcon® 2013 Editors’ Awards

    Friday, May 10, 2013
    Technical Article
    Marian Nardozzi
    Pittcon® offers many different award ceremonies for outstanding scientific achievement to members of the scientific community; however, there is only one award for innovations in instrumentation. The... read more

  • Sample Prep for LC, GC, and SFC at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    At Pittcon® 2013, sample prep stood out as a major focus, perhaps because of the few advances in chromatography instrumentation. In addition, some sample preparation is spilling over into other ... read more

  • Automation in the Drug Discovery Process: Delivering Analytical Chemistry to Biologists and Beyond

    Friday, March 08, 2013
    Application Note
    Wendy Gaisford
    Over the past decade, advances in genomic- and proteomic-based research techniques and instrumentation have resulted in major breakthroughs in the elucidation of the structure and function of disease ... read more

  • High-Content Analysis (HCA 2013): 3-D Reduces the Gap Between In Vitro and In Vivo

    Tuesday, February 05, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The 10th High-Content Analysis meeting attracted about 300 scientists to San Francisco’s Fairmont Hotel (January 8–11, 2013). A Venn diagram of attendees would certainly include overlapping circles ... read more
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