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  • Automated Structure Verification by NMR, Part 1: Lead Optimization Support in Drug Discovery

    Tuesday, January 10, 2012
    Technical Article
    Philip Keyes Michael Messinger Gonzalo Hernandez
    The pharmaceutical industry has always relied on testing and evaluating novel compounds in a wide range of chemical space to feed its pipelines. read more

  • Spill Prevention: Engineering Decreased Risk of Uncontained Chemical Spills

    Monday, June 13, 2011
    Technical Article
    Vincent W. Caruso Edward C. Brown John P. Kay Michael A. Mancini James A. Westra Philip Keyes
    Safe solvent management and storage are significant concerns in the pharmaceutical industry, particularly when purification systems are run unattended and are supplied by large volumes of organic... read more

  • Plate Washing in 1536: Evaluation of a Double-Column Aspirator Head

    Thursday, October 22, 2009
    Application Note
    Michelle Batchlett Jason Cassaday Carissa Ohart Kurtis Berry Oleg Kornienko Jim Chang
    Plate assays (1536-well) that require washing (i.e., enzyme-linked immunosorbent assays [ELISAs] and cell-based), are not routinely implemented in high-throughput screening laboratories due to the ... read more

  • Minimizing Liquid Delivery Risk: Operators as Sources of Error

    Saturday, September 01, 2007
    Technical Article
    Wendy Vaccaro
    This is the third in a series of articles entitled “Minimizing Liquid Delivery Risk,” addressing the most common causes of liquid delivery error and providing guidance on how to address and overcome ... read more

  • Multicapillary Columns for Chromatography

    Tuesday, March 01, 2005
    Technical Article
    Yuri P. Belov Marina M. Ulyanova Vladimir N. Sidelnikov
    The principles and theory of high-speed capillary chromatography have been known since the 1960s. To realize the maximum speed capabilities, it is necessary to use capillaries with a diameter of ... read more

  • Rapid Testing of Toxic Chemicals

    Tuesday, March 01, 2005
    Application Note
    Nathalie Boucher Lucie Lorrain Marie-Eve Rouette Elisabeth Perron Nancy Déziel Louis Tessier François Bellemare
    The measurement of chlorophyll fluorescent signals from photosynthetic enzyme complexes (PEC) has becomeone of the most powerful indicators for ecophysiologists. read more

  • Miniaturized FTIR for Maximized Productivity

    Tuesday, March 01, 2005
    Application Note
    Ken Fredeen John S. Seelenbinder Mark L. Norman
    In today’s fast-paced business environment, many companies are under pressure to improve their productivity. This is especially true in the pharmaceutical industry, where reducing time-to-market ... read more

  • LC-MS With Simultaneous Electrospray and Atmospheric Pressure Chemical Ionization

    Tuesday, March 01, 2005
    Technical Article
    Wayne P. Duncan Patrick D. Perkins
    Today, liquid chromatography-mass spectrometry with electrospray ionization (LC-ESI-MS) is increasingly being used as the technique of choice for high-throughput pharmaceutical analysis. read more
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