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  • High-Throughput Tools for Optimizing Drug Nanosuspensions

    Thursday, February 19, 2015
    Application Note
    Dennis H. Leung Timothy Rhodes Annette Bak
    Inadequate absorption and bioavailability often make it difficult to deliver the drug to the target in vivo and pose significant challenges to the discovery and development of new drugs. A number of ... read more

  • Thorough Risk Assessment Supports At-Scale Process Safety

    Wednesday, July 16, 2014
    Application Note
    Urs Groth
    It goes without saying that in any manufacturing environment no one sets out to design an unsafe process. However, it is not enough to ensure a process will be safe under normal operating conditions. read more

  • Evaluation of Antibiotic-Free Cell Cultures in Manual and Automated Cell Handling

    Monday, October 28, 2013
    Application Note
    Kerstin Thurow Ricarda Lehmann Leonie Vetter Luisa Person
    Antibiotics are frequently added to cell culture media; the greatest benefit to this is that it suppresses contamination. However, routine use of antibiotics is associated with the development of ... read more

  • Rapid Enantiomeric Excess Determination of D- and L-Proline Using Electrospray Ionization–Mass ...

    Thursday, September 01, 2011
    Technical Article
    Heidi Fleischer Kerstin Thurow
    The enantiomeric composition of proline is commonly determined using conventional analytical methods such as HPLC, GC, and CE. read more

  • Increased Throughput in Method 8270 Analysis

    Monday, January 01, 2007
    Application Note
    William D. Goodman Frank DeLorenzo
    Method 8270 is a GC-MS method created by the U.S. EPA Office of Solid Waste for the analysis of semivolatile organics by gas chromatography-mass spectrometry. read more

  • Automated Chemical Ionization in GC-MS

    Monday, January 01, 2007
    Application Note
    Chris Sandy Jean-Francois Garnier Bernhard Rothweiler Fred Feyerherm Sihem Ben Mahmoud Harry F. Prest
    Gas chromatography with mass spectrometric detection using chemical ionization (CI) has demonstrated great utility in a wide variety of application areas ranging from forensics to environmental to ... read more

  • A Multifrequency Temperature-Modulated Technique For DSC

    Sunday, January 01, 2006
    Application Note
    Markus Schubnell Christoph Heitz Thomas Hütter Steven Sauerbrunn Juergen E.K. Schawe
    In conventional differential scanning calorimetry (DSC), a sample is subjected to a temperature program with a constant heating rate. As a result, the DSC instrument delivers an output signal, which, ... read more

  • A High-Sensitivity Sensor for DSC

    Friday, August 05, 2005
    Application Note
    Rudolf Riesen Blaine Weddle
    A dramatic increase in sensitivity at low signal noise without a significant loss in signal resolution has been achieved with the HSS7 high-sensitivity sensor. read more
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