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  • Meeting the Challenge of Biological Changes Postsampling

    Friday, May 16, 2014
    Application Note
    Marcus Söderquist
    Understanding the role of proteins, peptides, and their post-translational modifications, e.g., phosphorylations, in normal and diseased biological samples is crucial to elucidate in vivo biological ... read more

  • Sample Processing at Pittcon® 2014

    Tuesday, May 06, 2014
    Application Note
    Robert L. Stevenson, Ph.D.
    The tenfold increase in speed for the analytics (GC, HPLC, and SFC [supercritical fluid chromatography], all with MS) over the last decade has shifted the choke point in many workflows from analytics ... read more

  • Sample Prep for LC, GC, and SFC at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    At Pittcon® 2013, sample prep stood out as a major focus, perhaps because of the few advances in chromatography instrumentation. In addition, some sample preparation is spilling over into other ... read more

  • New Instrumentation and Applications at HPLC 2012

    Friday, August 10, 2012
    Technical Article
    Robert L. Stevenson, Ph.D.
    A marketplace is usually dynamic, with a cross-current of disparate interests meeting to find mutual satisfaction. read more

  • Optimizing the Western Blotting Procedure: Solutions for Faster Western Blots

    Monday, July 30, 2012
    Application Note
    Catherine Shaffer
    Advances in technology make the Western blotting procedure both faster and quantitative. Solutions for faster Western blots include faster transfer equipment and faster reagents. Purchasing a ... read more

  • 21st Century Gel Documentation in Research and Production Environments

    Friday, March 27, 2009
    Application Note
    John Pizzonia
    Standard gel documentation has been performed for decades with some variation of the “camera on a stick” approach, that is, the camera and lens are positioned above the target pointed downward at the ... read more

  • Advances in Microscale Protein Fractionation and Analysis

    Monday, January 01, 2007
    Technical Article
    Julie S. Hey
    Fractionation is an essential step in the identification of proteins and their subsequent structural characterization. read more

  • Increased Throughput in Method 8270 Analysis

    Monday, January 01, 2007
    Application Note
    William D. Goodman Frank DeLorenzo
    Method 8270 is a GC-MS method created by the U.S. EPA Office of Solid Waste for the analysis of semivolatile organics by gas chromatography-mass spectrometry. read more

  • Automated Chemical Ionization in GC-MS

    Monday, January 01, 2007
    Application Note
    Chris Sandy Jean-Francois Garnier Bernhard Rothweiler Fred Feyerherm Sihem Ben Mahmoud Harry F. Prest
    Gas chromatography with mass spectrometric detection using chemical ionization (CI) has demonstrated great utility in a wide variety of application areas ranging from forensics to environmental to ... read more

  • Cost Benefit Analysis of a Multicapillary Electrophoresis System

    Thursday, June 01, 2006
    Technical Article
    Varouj Amirkhanian Ming Lui Andras Guttman Eszter Szantai
    Today’s genomics laboratories require high throughput, cost-effectiveness, detection sensitivity, and high resolution. read more

  • Tips to Prevent Streaking on 2-D Gels

    Tuesday, November 01, 2005
    Application Note
    Tom Berkelman Mary Grace Brubacher Haiyin Chang Tim Cross William Strong
    The most common problem encountered with 2-D gels is protein streaking, whether in the horizontal or vertical direction. read more

  • An Automated Alternative to SDS-PAGE for Protein Analysis

    Tuesday, March 01, 2005
    Technical Article
    Sang Jeong Sherri Biondi Jim Mikkelsen Bahram Fathollahi Adrian Winoto Michael Spaid Andrea Chow
    Now that the Human Genome Project is finished, the next important phase is understanding the expression and function of proteins. read more
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