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LabTips: Glass, Plastic, Septa Basics
Manufacturing glass and plastic vials and caps for use in pharmaceutical, petrochemical, environmental, food, diagnostic, life science and other laboratories in industrial, government and university ...
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Weighing in on Weighing
Weighing ingredients properly is a critical part of manufacturing pharmaceutical products.
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2-D NMR Developments Improve Monoclonal Antibody Characterization
Ten years ago, industry commentators noted the increasing importance of biologics, and monoclonal antibodies (mAbs), in particular.
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High-Throughput Drug Screening of Multicellular Tumor Spheroids
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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Statistics in the Laboratory: The Capability of a Measurement Process
Measurement processes must be fit for use. In this column, we’ll develop some quantitative statistical descriptors of the capability of a measurement process to be valid for its intended purpose.
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Cancer Throws Another Curveball
Metastasis of solid cancer tumors is a crucial step in progression and generally portends poor patient outcome.
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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NGS Library Validation Using Automated Capillary Gel Electrophoresis
Next-generation sequencing (NGS) is widely used in genomics, epigenetics and transcriptomics, etc., and also in such clinical diagnostics applications as cancer screening and drug development.
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Proper Monitoring of Refrigerators and Freezers to Protect Valuable Biomedical Inventory
Best practices for cold storage must be followed to protect valuable samples. Important goals are to avoid degradation, which stems from high and low temperature extremes, and prevent loss of potency ...
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High-Throughput VOC and Inorganic Gas Analysis: Automated SIFT-MS
A sensitive technique called selected ion flow tube mass spectrometry (SIFT-MS) allows the direct, real-time monitoring of inorganic gases and volatile organic compounds (VOCs), with no need to ...
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Bringing Raman Spectroscopy to the Undergraduate Laboratory
Designed specifically for the educational environment, a Raman tool incorporates a safe way to operate laser in a durable, open package, offered at about a third of the price of a traditional Raman ...
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Compact HPLC Systems for the Analysis of Pesticides, Dyes and Drugs
The analyzer described in this article provides fast analysis of food dyes commonly used in products in the beverage and pharmaceutical industries, as well as high-resolution separation of a complex ...
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Defining Cannabis Standards in a Green Market
Cannabis labs have spent years optimizing their methods for a wide variety of matrices without the benefit of tailored reference standards, application notes or white papers. This is now changing, as ...
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Individual Cell Analysis for Protein Expression and Cell Health Markers
The Muse instrument uses microcapillary fluidics and preoptimized reagents to create an inexpensive, compact, portable cell analyzer that requires minimal setup and no expertise to operate.
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Expansion of Human Bone Marrow-Derived Mesenchymal Stem Cells in a Single-Use Bioreactor
One of the challenges in providing human mesenchymal stem cells (hMSCs) for curative use is the production of large quantities of cells in a robust manner.
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