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Top Considerations When Automating Your Real-Time PCR Workflow
With the increasing importance of large-scale data generation, many pharmaceutical labs are using robots to speed data collection. One such strategy is to automate the real-time PCR workflow.
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Observations on Regulatory RNAs 2014
The last two decades have been exciting times as simplistic genomic models were updated to explain mechanistic details. Along the way, we discarded the expectation that sequencing the genome would ...
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Analytical Method Development in the Quality by Design Framework
The development of analytical methods in the Quality by Design (QbD) framework is currently gaining great momentum in the pharmaceutical industry. Presented here is a case study in which a ...
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Electrochemical Determination of Acetaminophen Using Gold Nanoparticles–Multiwall Carbon Nanotubes Modified Glassy Carbon Electrode
Since their discovery in 1991, carbon nanotubes (CNTs) have been extensively studied for use in emitting devices, energy storage, sensor field, and biological and biomedical applications.
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LIMS and the New Monitoring Paradigm for Pharmaceuticals and Personal-Care Products
A recent study published in the journal Environmental Pollution identified 56 active pharmaceutical ingredients (APIs) in effluent samples from 50 large wastewater treatment plants across the U.S. ...
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Why You Should Know about the Excipients Search Tool
The American Pharmaceutical Review Excipients Search Tool is the first commercially accessible search tool featuring the latest excipients available for research and purchase from top excipients ...
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Use of Microcalorimetry to Study Protein Stability
Differential scanning calorimetry (DSC) is used in the pharmaceutical, polymer and biotechnology industries to study the effect of temperature on a variety of solids or liquids, including those that ...
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Analysis of Hemoglobin Variants using an Automated Sample Preparation Workstation Coupled to LC-MS
Hemoglobinopathies are genetic defects that result in one of the chains of the hemoglobin molecule. These are usually single-gene disorders, such as sickle cell disease, and they are usually ...
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Importance of Laboratory Compliance
Before analytical results can be generated, a laboratory requires a suitable calibrated instrument, a trained analyst, an approved/validated method, appropriate reference materials, a standard ...
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Simplified Bioanalytical Sample Preparation
The complexity of biological samples can pose challenges to downstream analysis in the pharmaceutical industry. Bioanalytical and drug metabolism and pharmacokinetics (DMPK) groups often work with ...
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Use of Transgenic Mouse Models to Test for Carcinogenicity
Carcinogenicity studies are conducted to determine the tumorigenic potential of pharmaceuticals and chemicals, as required by regulatory authorities. Two-year bioassays in rats and mice have ...
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Biotechnologists, Take a Bow
Blincyto has a unique mechanism of action, according to Anthony S. Stein, M.D., of the City of Hope Medical Center in Duarte, Calif.
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Holistic Lab Review Helps Avoid Out-of-Spec (OOS) Results
Pharmaceutical laboratories are often asked to be more productive despite greater budget restrictions, a situation that can lead to crisis management, as opposed to continual assessment and ...
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Boom or Bust?
Pot is becoming big business. Four states—Colorado, Oregon, Alaska and Washington, as well as the District of Columbia—have legalized the recreational use of marijuana.
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Big Data at the 2015 AAPS National Biotechnology Conference
The 2015 AAPS National Biotechnology Conference opened with an extended session on the utility of big data technology in the creation of a modern pharmaceutical industry.
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