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  • Automated Structure Verification by NMR, Part 1: Lead Optimization Support in Drug Discovery

    Tuesday, January 10, 2012
    Technical Article
    Philip Keyes Michael Messinger Gonzalo Hernandez
    The pharmaceutical industry has always relied on testing and evaluating novel compounds in a wide range of chemical space to feed its pipelines. read more
  • Spill Prevention: Engineering Decreased Risk of Uncontained Chemical Spills

    Monday, June 13, 2011
    Technical Article
    Vincent W. Caruso Edward C. Brown John P. Kay Michael A. Mancini James A. Westra Philip Keyes
    Safe solvent management and storage are significant concerns in the pharmaceutical industry, particularly when purification systems are run unattended and are supplied by large volumes of organic... read more
  • Plate Washing in 1536: Evaluation of a Double-Column Aspirator Head

    Thursday, October 22, 2009
    Application Note
    Michelle Batchlett Jason Cassaday Carissa Ohart Kurtis Berry Oleg Kornienko Jim Chang
    Plate assays (1536-well) that require washing (i.e., enzyme-linked immunosorbent assays [ELISAs] and cell-based), are not routinely implemented in high-throughput screening laboratories due to the ... read more
  • Minimizing Liquid Delivery Risk: Operators as Sources of Error

    Saturday, September 01, 2007
    Technical Article
    Wendy Vaccaro
    This is the third in a series of articles entitled “Minimizing Liquid Delivery Risk,” addressing the most common causes of liquid delivery error and providing guidance on how to address and overcome ... read more
  • Increased Throughput in Method 8270 Analysis

    Monday, January 01, 2007
    Application Note
    William D. Goodman Frank DeLorenzo
    Method 8270 is a GC-MS method created by the U.S. EPA Office of Solid Waste for the analysis of semivolatile organics by gas chromatography-mass spectrometry. read more
  • Automated Chemical Ionization in GC-MS

    Monday, January 01, 2007
    Application Note
    Chris Sandy Jean-Francois Garnier Bernhard Rothweiler Fred Feyerherm Sihem Ben Mahmoud Harry F. Prest
    Gas chromatography with mass spectrometric detection using chemical ionization (CI) has demonstrated great utility in a wide variety of application areas ranging from forensics to environmental to ... read more
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