The high specificity of LC/MS is relied upon for detecting illicit compounds. However, issues related to method robustness and matrix interference have driven the need for developing better analytical methods that can accommodate an ever changing list of synthetic compounds, along with heightened awareness of the need for efficient sample preparation. The SPE technology used in this work provides extracts free of endogenous matrix that can interfere with quantitation, decrease sample throughput and reduce column lifetime. The subsequent high-efficiency separation results in a sensitive LC/MS method for the direct analysis of eight different analogs of NBOMe hallucinogens.
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