Investigating Intracellular Ice Formation with Cryomicroscopy

Cryopreservation is the preservation of living and structurally intact cells and tissues by cooling to very low temperatures (as low as -196°C). A key challenge facing cryopreservation research is intracellular ice formation (IIF), which damages cells and is the primary cause of death of cells cryopreserved in solution. Research is focusing on investigating the mechanisms of IIF, and how a better understanding of these processes can improve cryopreservation protocols in a range of medical applications, such as storage of red blood cells (RBCs).

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