While there are several different gasses that can be used as a mobile phase in gas chromatography (GC), helium has long prevailed as the most popular choice due to a number of factors including inertness, safety, purity and overall excellent performance.1 Despite its advantages, the use of helium carrier gas for GC analysis also comes with its challenges, including persistent supply chain issues and higher cost compared to alternatives such as hydrogen. The globe is currently experiencing its fourth major helium shortage since 2006, dubbed “Helium Shortage 4.0,” which was spurred by events including the unexpected shutdowns of major helium plants in Texas and Russia, and exacerbated by the war in Ukraine.2 These challenges have led many labs to consider switching from helium to an alternative carrier gas, with hydrogen being one of the most promising alternative choices.
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