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  • Identification of Cancer Stem Cells Within Mixed Populations Using Live Cell RNA Detection

    Thursday, January 09, 2014
    Application Note
    Don Weldon Steve McClellan
    Despite the ubiquity of studies measuring mRNA and miRNA levels, many current techniques require cell lysis and are enormously disruptive to the cells being studied. read more

  • An Improved Method to Generate Virus-Free Human iPSCs

    Monday, November 03, 2014
    Application Note
    Vi Chu Nick Asbrock Min Lu
    Induced pluripotent stem cells (iPSCs) are offering new opportunities in both research and clinical applications. Researchers are using these cells for drug and toxicity screening, as well as for ... read more

  • Evaluation of an Automated Solid-Phase Extraction Method Using Positive Pressure

    Wednesday, April 08, 2015
    Application Note
    Heidi Fleischer Kerstin Thurow Ellen Vorberg Carolin Gallert Thomas Roddelkopf Steffen Junginger
    Investigations for the determination of drugs in real samples, while gaining in importance, are limited by time and sample throughput. In response to this, the authors developed an automated solid-... read more

  • Screening Live Cells Using RNA Detection Probes

    Friday, June 12, 2015
    Application Note
    Don Weldon Harald Lahm
    RNA expression is the next frontier in biomarker development because it offers an indication of cellular intent. mRNA expression, in particular, can show how a cell responds to its environment or ... read more

  • Quantitative Analysis of H2A.X and ATM DNA Damage Signals Using Benchtop Flow Cytometry

    Friday, September 25, 2015
    Application Note
    Mark Santos Wenying Zhang
    Assessing the level of DNA damage present in cells is integral to understanding the molecular mechanisms involved in the genome repair process and consequences for cell fate. read more

  • Pittcon® 2011 Editors’ Awards: A Two-Way Tie for the Gold Award

    Friday, April 01, 2011
    Technical Article
    Jeanely Hunt, MS, MBA
    Pittcon 2011 was held March 13–18, 2011 at the Georgia World Congress Center in Atlanta, GA. The exhibition displayed an assortment of laboratory products, including anything from small plastic ... read more

  • Analysis of Piperine in Peppers Using On-Line SFE-UHPLC With Photodiode Array Detection

    Tuesday, February 01, 2011
    Application Note
    Takayuki Yamaguchi Kazutoshi Kamezawa Keijin Iwaya Yasuyo Sato Toshihiko Miyaji Masao Bounoshita David J. Tognarelli Muneo Saito
    Ultrahigh-performance liquid chromatography (UHPLC) is a separation technique that utilizes columns packed with microparticles (<2 µm in diameter), as provided by the xtreme liquid chromatography (x-lc™) system (jasco corp., tokyo, japan) µm="" in="" diameter),="" as="" provided="" by="" the="" xtreme="" liquid="" chromatography="" (x-lc™)="" system="" (jasco="" corp.,="" tokyo,="">... read more

  • Optimizing HPLC Sample Preparation

    Monday, February 06, 2012
    Technical Article
    Caitlin Smith
    Sample preparation is an important component for analysis in high-performance liquid chromatography (HPLC)/ultra high-performance liquid chromatography (UHPLC). This article outlines commonly used ... read more

  • New Products at Pittcon® 2011

    Thursday, March 10, 2011
    Application Note
    Jeanely Hunt, MS, MBA
    The following includes some of the latest advances in laboratory instrumentation debuting at Pittcon® 2011. read more

  • Use of Automated Solid-Phase Extraction and GC-MS/MS to Evaluate Nitrosamines in Water Matrices

    Tuesday, March 06, 2012
    Technical Article
    Janie C. Holady Rebecca A. Trenholm Shane A. Snyder
    An analytical method for detecting nitrosamines was demonstrated in various water matrices: finished drinking, surface, and treated wastewater effluent. read more

  • Micro RNA Profiling with a Multiplexed Assay

    Monday, March 03, 2014
    Application Note
    Mark Santos
    From the discovery of new miRNAs to clarifying their biological roles and utility as biomarkers, micro RNA (miRNA)-based research is undergoing a period of change. Rigorous methods are therefore ... read more

  • Cellular Reprogramming: Opportunities and Challenges

    Monday, May 09, 2011
    Application Note
    Vi Chu Amy Noble Louise Rollins
    In 2007, researchers created the first human induced pluripotent stem cells (iPS cells) by infecting skin cells with four transcription factors (Oct-4, Klf4, Sox-2, and c-Myc). read more

  • General Laboratory Equipment: Innovation Showcase

    Monday, May 09, 2011
    Technical Article
    Jeanely Hunt, MS, MBA
    Each year, manufacturers and distributors flesh out many innovations for the laboratory, ranging from simple accessories to large, more complex instrumentation. read more

  • Focus on Columns and Consumables at Pittcon® 2011

    Tuesday, May 10, 2011
    Technical Article
    Robert L. Stevenson, Ph.D.
    Columns, chemicals, and consumables (CCCs) account for more than 30% of the chromatography market. read more

  • Pittcon® 2012: Laboratory Instrumentation and Equipment Product Showcase

    Monday, May 07, 2012
    Technical Article
    Jeanely Hunt, MS, MBA
    Pittcon® 2012 was held March 11–15, 2012 at the Orange County Convention Center in Orlando, Florida. The following product showcase provides a brief outline of new and current laboratory equipment and... read more

  • Matrix Degradation Assays for Investigating Cell Invasion

    Tuesday, November 01, 2011
    Application Note
    Jun Ma Luke Armstrong Janet Anderl
    Tumor metastasis, inflammation, and development are accompanied by the invasion of cells through the extracellular matrix. read more

  • Improved Long-Term Culture Using A Microfluidic Platform

    Monday, October 07, 2013
    Application Note
    Alex Mok Paul Hung Cindy Chen Sónia Gil Kathleen Ongena
    Precise and biologically relevant in vitro studies require the ability to analyze cell responses to perturbations over time. In order to achieve successful long-term cell culture and imaging, however,... read more

  • Multicapillary Columns for Chromatography

    Tuesday, March 01, 2005
    Technical Article
    Yuri P. Belov Marina M. Ulyanova Vladimir N. Sidelnikov
    The principles and theory of high-speed capillary chromatography have been known since the 1960s. To realize the maximum speed capabilities, it is necessary to use capillaries with a diameter of ... read more

  • Rapid Testing of Toxic Chemicals

    Tuesday, March 01, 2005
    Application Note
    Nathalie Boucher Lucie Lorrain Marie-Eve Rouette Elisabeth Perron Nancy Déziel Louis Tessier François Bellemare
    The measurement of chlorophyll fluorescent signals from photosynthetic enzyme complexes (PEC) has becomeone of the most powerful indicators for ecophysiologists. read more

  • Miniaturized FTIR for Maximized Productivity

    Tuesday, March 01, 2005
    Application Note
    Ken Fredeen John S. Seelenbinder Mark L. Norman
    In today’s fast-paced business environment, many companies are under pressure to improve their productivity. This is especially true in the pharmaceutical industry, where reducing time-to-market ... read more
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