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Title
Statistics in the Laboratory: The Capability of a Measurement Process
Tuesday, September 27, 2016
Stanley N. Deming
Measurement processes must be fit for use. In this column, we’ll develop some quantitative statistical descriptors of the capability of a measurement process to be valid for its intended purpose.
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Urinary Drug Testing: Small Changes for Big Improvements in Sensitivity
Tuesday, September 27, 2016
Jenny Cybulski
An oversight or mistake in drug testing can have dire consequences—a positive drug test can ruin the possibility of employment, turn an accident into a lawsuit, or cause a physician to discontinue ...
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
Friday, November 04, 2016
Michael Kowalski
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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Ten Tips for Proper Pipetting
Monday, November 07, 2016
A. Björn Carle
Pipetting proficiency is one of the most critical elements to ensure accuracy and precision, particularly in the face of high personnel turnover, growing laboratory workloads and increasingly complex ...
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The Myths and Truths of Measuring Pure Water
Monday, November 07, 2016
Gayle Gleichauf
Kim Knepper
Techniques such as liquid chromatography and mass spectrometry require ultrapure water (UPW) for trace-level analysis.
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Achieving Accuracy and Reproducibility With Electronic Pipettes
Monday, November 07, 2016
Nora Meneceur
Beatrice Guieu-Presle
Researchers are continuously seeking ways to improve efficiency while ensuring that their methods are reliable and their research is reproducible.
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Extraction of Planar Pesticides From Spinach and Fresh Oregano Using QuEChERS Methodology With a Novel Carbon Adsorbent
Monday, November 07, 2016
Michael Ye
Jennifer Claus
Although vital to plant life, the presence of chlorophyll in GC/MS analysis is highly problematic.
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For Accurate Cell-Based Assay Results, Transfer Technique Matters
Wednesday, November 09, 2016
John Lesnick
From smaller-scale assays to industrial-scale screening operations, cell-based assays are critical for applications that include elucidating basic mechanisms of cell function, target validation and ...
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Detection of Subvisible Particulates in Bioformulations to Ensure Safety
Monday, October 29, 2018
Kent Peterson
The biopharmaceutical industry exercises great care to ensure the long-term stability, efficacy, and safety of therapies, from formulation development to patient administration.
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Best Practices to Ensure Freezers Provide Optimal Storage
Thursday, October 25, 2018
Michael Steinert
Reviewing best practices and following the steps outlined in the freezer’s manual can provide optimal storage of valuable samples for many years.
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Quality Standards for Primary Cell Starting Material
Thursday, November 01, 2018
Dominic Clarke
Marie Aragon
The repercussions of apheresis procedures, instrumentation, cell collection, and quality control criteria on primary cell starting material quality are examined.
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Streamlined Protein Purification
Friday, November 02, 2018
Tom Valorose
Innovative spin device designs minimize or potentially eliminate the incidence of protein aggregation.
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The Evolution of Spectroscopy: A New Technique for Biotherapeutic Formulation
Friday, November 02, 2018
Eugene Ma
Brent Kendrick
Libo Wang
By providing highly sensitive, repeatable characterization across a wide dynamic range, a new IR technique offers a way to simplify the analytical workflow associated with biopharmaceutical ...
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Removing the Barriers to High-Sensitivity Microflow Liquid Chromatography/Mass Spectrometry
Wednesday, May 01, 2019
Tyler Davis
Microflow LC provides sensitive analysis of biologics and small-molecule drugs.
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Pesticide Analysis in Cannabis: Extracting the Pesticide From the Flower
Monday, April 29, 2019
Michael Steinert
The QuEChERS and SPE methods are the most popular methods for the cleanup phase when analyzing pesticides in cannabis.
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Quantitative Analysis of Cannabinoids in Edibles Using Thermal Desorption-GC/MS
Monday, April 08, 2019
Rojin Belganeh
William Pipkin
Terry Ramus
A simple, rapid, and accurate thermal desorption-GC/MS technique is described for the determination of cannabinoids
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Reducing the Total Cost of Biological Safety Cabinet Ownership
Tuesday, May 01, 2018
Martin Cole
Minimizing the total cost of BSC ownership can help lab managers realize their sustainability goals through energy savings and reduced heat emissions.
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Strategies for Deep Imaging With Multiphoton Microscopy
Wednesday, May 02, 2018
Carlo Amadeo C. Alonzo
Multiphoton microscopy can inform strategies for maximizing depth penetration through highly scattering specimens.
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Optical Efficiency Effects on Infrared Diffuse Reflection Spectroscopy Signal-to-Noise Ratio
Thursday, May 03, 2018
Dalia K. Maraoulaite
Robert L. White
This paper describes the impact of typical DRIFTS optical configurations on measurement SNR.
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Improving Protein Purification Efficiency of Biologics
Tuesday, May 01, 2018
Candice Cox
Multi-D chromatography reduces time to results and increases the robustness and reproducibility of small-batch biologic purification.
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