Application Notes

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Breakthrough Technology for Bottom-Up Proteomics and Small Molecule Research
Tuesday, August 01, 2006
Alexander Makarov Helmut Muenster
High mass resolution is a prerequisite for high mass accuracy. Both are key for the analysis of unknown samples. High resolution enables the separation and detection of isobaric signals that are ... Read More
Stability of Salicylic Acid and Magnesium Stearate by DSC
Saturday, April 01, 2006
Steven Sauerbrunn Lloyd MacPherson
The first step in developing effective pharmaceutical formulations is the discovery of the active agent. Read More
Evaluation of the Accuracy and Reproducibility of a High-Temperature Differential Scanning Calorimeter by Heat Capacity Measurements
Tuesday, August 01, 2006
Susan Jacob Mark E. Schlesinger
Differential scanning calorimetry (DSC) is used to determine thermodynamic properties including specific heat, glass transition, and melting points of a variety of materials. The need for accurate ... Read More
The Impact of Chiral Supercritical Fluid Chromatography in Drug Discovery: From Analytical to Multigram Scale
Thursday, June 01, 2006
Dauh-Rurng Wu Leslie Leith Balu Balasubramanian Todd Palcic David Wang-Iverson
A significant responsibility for the analytical group within Drug Discovery Chemistry at Bristol Myers-Squibb (Princeton, NJ) is the chromatographic purification of chiral compounds, both ... Read More
A Multifrequency Temperature- Modulated Technique For DSC
Sunday, January 01, 2006
Markus Schubnell Christoph Heitz Thomas Hütter Steven Sauerbrunn Juergen E.K. Schawe
In conventional differential scanning calorimetry (DSC), a sample is subjected to a temperature program with a constant heating rate. As a result, the DSC instrument delivers an output signal, which, ... Read More
A New Approach to Atomic Force Microscopy for Nanometrology Applications
Friday, April 01, 2005
Paul West Zhiqiang Peng Natalia Starostina
Since the invention of the atomic force microscope (AFM), the use of high-resolution topographic images has become the standard in microscopy and surface science publications. Read More
Use of New Scanning Technology to Elucidate Ion Channel Mobility
Friday, April 01, 2005
Angela Goodacre Kristen M.S. O’Connell Michael M. Tamkun
Fluorescent chromophores fused to specific proteins have greatly increased our ability to image dynamic events within the living cell. Read More
Rapid Testing of Toxic Chemicals
Tuesday, March 01, 2005
Nathalie Boucher Lucie Lorrain Marie-Eve Rouette Elisabeth Perron Nancy Déziel Louis Tessier François Bellemare
The measurement of chlorophyll fluorescent signals from photosynthetic enzyme complexes (PEC) has becomeone of the most powerful indicators for ecophysiologists. Read More
Miniaturized FTIR for Maximized Productivity
Tuesday, March 01, 2005
Ken Fredeen John S. Seelenbinder Mark L. Norman
In today’s fast-paced business environment, many companies are under pressure to improve their productivity. This is especially true in the pharmaceutical industry, where reducing time-to-market ... Read More
Quantifying the Benefits of Standardizing on LIMS
Thursday, February 03, 2005
Jim Neville Catherine Brown
The marked trend by organizations toward standardizing on critical information technology (IT) systems and applications has now moved into the laboratory environment. Read More
Synthesis of Mn²⁺-Doped PbS Quantum Dots and Their Spectroscopic Properties
Tuesday, February 01, 2005
Curtis Deer Raymond Sung Pedro Gonzalez Beerman Subra Muralidharan
Quantum dots are semiconductor nanocrystals that have size-dependent properties, unlike bulk materials, as indicated by the well-studied CdSe system. Read More
Compact Spectroscopy Instrumentation: On-Board Smarts or External Computer?
Tuesday, February 01, 2005
Hector Lara Ron Hartmayer
Compact, array-based spectrometers continue to develop in response to advances in detector, microprocessor, storage, and display technology. Read More
New Frontiers in Chromatography
Tuesday, February 01, 2005
Michael E. Swartz Brian Murphy
High-performance liquid chromatography (HPLC) has proven to be the predominant technology used in laboratories worldwide during the past 30-plus years. Read More
An NPDES Distillation Method for Measuring Total Cyanide in Water
Saturday, October 01, 2005
John R. Sebroski Karin L. Bogren
Used for total cyanide distillation, the MICRO DIST system was granted National Primary Drinking Water Regulations (NPDWR) approval in 2003 and is expected to receive nationwide Tier III approval for ... Read More
Ten Steps to Maintaining Gas Stream Purity
Friday, September 23, 2005
Frank Kandl
Many problems in gas chromatography follow a cylinder change-out, prompting chemists to buy ever-higher purity grades of gas. Read More
Creating Rich Web-Based LIMS With Programmable XML Technologies
Thursday, September 01, 2005
Dinu Toiba
Laboratory information management systems convert mass amounts of data into analytical information useful throughout the enterprise. Read More
A High-Sensitivity Sensor for DSC
Friday, August 05, 2005
Rudolf Riesen Blaine Weddle
A dramatic increase in sensitivity at low signal noise without a significant loss in signal resolution has been achieved with the HSS7 high-sensitivity sensor. Read More
Optimizing the Sensitivity of an Evaporative Light Scattering Detector
Tuesday, October 12, 2004
Peter Froehlich Rodolphe Pennanec
The evaporative light scattering detector (ELSD) is a universal, mass-based detector for HPLC, ultraperformance liquid chromatography (UPLC), gel permeation chromatography (GPC), and supercritical ... Read More
What’s Happening in Chemometrics?
Wednesday, June 01, 2005
Susan Foulk
Chemometrics is the discipline associated with the application of mathematical and statistical methods to chemical measurements. Read More
TGA With Evolved Gas Analysis
Saturday, January 01, 2005
Tom Basalik
In thermogravimetric analysis (TGA), the weight of a sample is recorded as a function of temperature or time under defined atmospheric conditions. Read More