Scott Hickman

Scott Hickman

Scott Hickman is global market segment manager for toxicology, BioReliance (part of Sigma-Aldrich), 14920 Broschart Rd., Rockville, Md. 20850-3349, U.S.A.; tel.: 301-738-1000; fax: 301-610-2590; e-mail: [email protected]; www.bioreliance.com. BioReliance has more than 15 years of experience working with transgenic models for carcino- genicity assessment. Through the National Toxicology Program, the company was involved in the

initial validation of the p53 +/- and Tg.AC models and, later, validation of the Tg.rasH2 model. The validation work was part of the Interna- tional Life Sciences Institute (ILSI) program, the results of which led to changes in the International Conference on Harmonisation (ICH) guidelines and accep- tance by international regulatory bodies of these models as alternatives to the two-year mouse bioassay.

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