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The Impact of Chiral Supercritical Fluid Chromatography in Drug Discovery: From Analytical to Multigram Scale
Thursday, June 01, 2006
A significant responsibility for the analytical group within Drug Discovery Chemistry at Bristol Myers-Squibb (Princeton, NJ) is the chromatographic purification of chiral compounds, both ...
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Development of an LC-ESI-MS-MS Method With Formate Anion Attachment for Detecting Neutral Molecules in Rat Plasma
Monday, May 01, 2006
Quantitative bioanalysis is the most important application area of liquid chromatography coupled with atmospheric pressure ionization (API) tandem mass spectrometric detection (LC-API-MS-MS) in ...
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Application of Difference Spectroscopy to Biopharmaceutical Formulation Development
Monday, May 01, 2006
Spectroscopy is increasingly being used in biopharmaceutical formulation development to characterize protein structure and the response of structure to the formulation configuration.
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Improving and Speeding up the Characterization of Substances, Materials, and Products: Benefits and Potentials of High-Speed DSC
Monday, April 10, 2006
High-speed calorimetry, and specifically high-speed differential scanning calorimetry (DSC), has received a great deal of attention in recent years.
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Improved Capabilities of Noncell-Based Permeability Assays
Monday, April 10, 2006
Assays that predict passive absorption of orally administered drugs have become increasingly important in the early drug discovery process.
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Managing Workstation Exhaust at Biosafety Level Laboratories
Monday, April 03, 2006
Biosafety level laboratories, particularly Levels3 and 4, present special problems for managing workstation fumehood exhaust.
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A Colloid Stability Analyzer for the Analysis of Stability of Complex Formulations
Saturday, April 01, 2006
Scientists in the biotechnology, pharmaceutical, health-care, food and beverage, chemical and petrochemical, polymer, and other industries have spent considerable time studying the relationship ...
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Comprehensive Two-Dimensional Gas Chromatography With a Simple Fluidic Modulator
Saturday, April 01, 2006
Gas chromatography is a simple yet powerful technique for analyzing complex mixtures of volatile and semivolatile compounds.
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Stability of Salicylic Acid and Magnesium Stearate by DSC
Saturday, April 01, 2006
The first step in developing effective pharmaceutical formulations is the discovery of the active agent.
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Three-Dimensional Elemental Imaging Using a Confocal X-Ray Fluorescence Microscope
Saturday, April 01, 2006
Micro X-ray fluorescence (MXRF) is a powerful elemental technique that can nondestructively provide both single-point spectra and full spectral elemental maps.
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A High-Throughput Device for Processing Samples on Solid Supports
Saturday, April 01, 2006
Crime statistics now support the effectiveness of aggressively analyzing breaking-and-entering cases and developing genotype databases of these felons.
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The Future of Information Technology: Selecting a Forward- Looking LIMS Vendor
Friday, March 10, 2006
Most sophisticated LIMS purchasers have a well-developed methodology for evaluating which system best meets their needs.
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Advanced Dryness Detection for Improved Throughput and Yield During Evaporation
Saturday, March 04, 2006
In many laboratories across a wide range of disciplines, removal of solvent from dissolved sample is a routine, daily procedure.
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Increasing the Stability of Liquid Stationary Phases for Improved Stability in High-Temperature GC
Wednesday, March 01, 2006
The attempt to stabilize stationary phases for use in gas chromatography is ongoing.
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Aligning Ultrafast NMR Spectroscopy and Cold Probe Technology to Reveal the Mysteries of Protein Dynamics
Wednesday, March 01, 2006
The understanding of protein dynamics, the way these molecules fold to form a stable structure, interact with other molecules, or undergo changes during enzyme activity, etc., in their native ...
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