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Isothermal Titration Calorimetry: An Indispensable Tool for Biological Pathway Research and Drug Development
Monday, October 02, 2017
Verna Frasca
As our knowledge of the genetic and molecular basis of disease continues to grow, drug development programs focus increasingly on those proteins associated with disease states.
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Automated Nephelometric Turbidity Measurement of Biotherapeutics Formulations
Friday, September 29, 2017
Daniel Kinder
With accurate turbidity data, the Freeslate biologics formulation workstation provides rapid sample preparation and analysis to support drug discovery and development activities.
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Product Contamination Visualization and Identification Using FTIR Microspectroscopy
Friday, September 29, 2017
David W. Schiering
Anthony W. Didomenico
John A. Seelenbinder
The identification of surface contamination particles on products is demonstrated using a new FTIR microspectroscopy accessory.
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Why Centrifugal Partition Chromatography is a Better Way to Extract Cannabidiol for Medical Research
Tuesday, September 05, 2017
Gregoire Audo
An alternative method for purifying cannabidiol and other cannabis extracts for research use is centrifugal partition chromatography
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A Virtual Instrument System for Testing the Validity of Drugs
Monday, September 04, 2017
Xun Gong
Wen Wu
Qijun Wu
Cheng Cai
A virtual instrument system for measuring the validity period of drugs enhances the performance of spectrophotometers.
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Long-Range Genomics Is Reviving a Lost Art
Wednesday, July 26, 2017
Chris Boles
The instrument described here was designed to treat DNA gently enough that users can prepare libraries of extremely large fragments directly from blood samples, bacterial and tissue cultures, or other...
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What Is Shear Rate and Why Is It Important?
Wednesday, June 07, 2017
David Moonay
Proper equipment selection may allow significantly different materials to be tested with one machine and geometry, merely by changing the testing speed or shear rate.
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A New Era in Filtered Fume Enclosure Safety
Wednesday, June 07, 2017
The latest ductless filtered fume enclosures are a vital resource in the safe and effective operation of modern industrial, educational, hospital, forensic, and pharmaceutical scientific laboratories.
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Fume Hoods and Cabinets
Friday, May 19, 2017
Biological safety cabinets and fume hoods protect samples, personnel and the laboratory environment from harsh chemicals or infectious substances.
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Best Practices: Incubators
Monday, May 08, 2017
Nancy Klimpel
Important parameters to consider when selecting an incubator are temperature accuracy, stability and uniformity.
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Individual Cell Analysis for Protein Expression and Cell Health Markers
Tuesday, March 21, 2017
Robin T. Clark
The Muse instrument uses microcapillary fluidics and preoptimized reagents to create an inexpensive, compact, portable cell analyzer that requires minimal setup and no expertise to operate.
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Proper Monitoring of Refrigerators and Freezers to Protect Valuable Biomedical Inventory
Friday, January 20, 2017
Rob Fusco
Best practices for cold storage must be followed to protect valuable samples. Important goals are to avoid degradation, which stems from high and low temperature extremes, and prevent loss of potency ...
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High-Throughput VOC and Inorganic Gas Analysis: Automated SIFT-MS
Friday, January 20, 2017
Mark J. Perkins
Vaughan S. Langford
Murray J. McEwan
A sensitive technique called selected ion flow tube mass spectrometry (SIFT-MS) allows the direct, real-time monitoring of inorganic gases and volatile organic compounds (VOCs), with no need to ...
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Bringing Raman Spectroscopy to the Undergraduate Laboratory
Friday, January 20, 2017
Brian Marquardt
Giora Proskurowski
Designed specifically for the educational environment, a Raman tool incorporates a safe way to operate laser in a durable, open package, offered at about a third of the price of a traditional Raman ...
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Compact HPLC Systems for the Analysis of Pesticides, Dyes and Drugs
Friday, January 20, 2017
Vlad Orlovsky
Yury Zelechonok
Konstantin Tchalukov
The analyzer described in this article provides fast analysis of food dyes commonly used in products in the beverage and pharmaceutical industries, as well as high-resolution separation of a complex ...
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NGS Library Validation Using Automated Capillary Gel Electrophoresis
Friday, November 11, 2016
Varouj Amirkhanian
Eric Tsai
Jemmie Chang
Alice Lin
Next-generation sequencing (NGS) is widely used in genomics, epigenetics and transcriptomics, etc., and also in such clinical diagnostics applications as cancer screening and drug development.
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
Friday, November 04, 2016
Michael Kowalski
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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High-Throughput Drug Screening of Multicellular Tumor Spheroids
Tuesday, September 27, 2016
Ana Maria P. Pardo
Hannah J. Gitschier
David H. Randle
Terry Riss
Three-dimensional (3-D) culture models are increasingly being used for drug discovery in oncology, as they better represent the complexity of the in vivo microenvironment of solid tumors.
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Statistics in the Laboratory: The Capability of a Measurement Process
Tuesday, September 27, 2016
Stanley N. Deming
Measurement processes must be fit for use. In this column, we’ll develop some quantitative statistical descriptors of the capability of a measurement process to be valid for its intended purpose.
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Weighing in on Weighing
Monday, September 26, 2016
Thomas Pertsch
Steffen Gloth
Weighing ingredients properly is a critical part of manufacturing pharmaceutical products.
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