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LIMS-BPMS Coupling: A Novel Approach for Flexible End-to-End Workflow Automation in Life Science Laboratories, Part 2
Monday, August 04, 2014
Kerstin Thurow
Silke Holzmüller-Laue
Bernd Göde
This article illustrates the potential of coupling a business process management system (BPMS) and LIMS, was presented in Part 1 of this paper (Am. Lab. 2014, 46[4], 26–9). Part 2 highlights the ...
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Measuring Absolute Molar Mass Using UHPLC SEC-MALS
Friday, June 13, 2014
Sophia Kenrick
Aym Berges
The characterization of aggregates or fragments in a biomolecular sample for applications such as bioanalytical chemistry and clinical diagnostics has traditionally been carried out using size ...
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Best Practices for the Use of Micropipets
Friday, June 13, 2014
A. Björn Carle
Doreen Rumery
George Rodrigues
Every day, air-displacement pipets are used to quantitatively dispense sample and reagent aliquots for reaction, routine analyses, and specialized tests.
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A Matter of Speed: Real-Time PCR for the Rapid Detection of Mycoplasma Contamination
Wednesday, June 11, 2014
Stephanie Schweizer
Alexandra Scholz
Mycoplasma are among the world’s smallest bacteria capable of independent reproduction. They belong to the class of Mollicutes and have a very slow and parasitic growth.
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Meeting the Challenge of Biological Changes Postsampling
Friday, May 16, 2014
Marcus Söderquist
Understanding the role of proteins, peptides, and their post-translational modifications, e.g., phosphorylations, in normal and diseased biological samples is crucial to elucidate in vivo biological ...
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Quality Control: An Important Success Factor in Nucleic Acid-Based Analysis
Tuesday, April 01, 2014
Carola Schade
Quality control (QC) is becoming increasingly important in nucleic acid-based testing. As detection technologies become more and more sensitive, final results are influenced not only by biological ...
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Single-Cell RNA Detection to Identify Cell Subpopulations in Heterogeneous Mixtures
Tuesday, March 25, 2014
Don Weldon
Victor Koong
Alex Ko
Yuko Williams
Laura White
Traditional RNA detection methods, which analyze RNA levels in lysed, permeabilized, or fixed cell samples, make it challenging to understand the role of one gene in the context of a tissue, organ, or...
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LIMS-BPMS Coupling: A Novel Approach for Flexible End-to-End Workflow Automation in Life Science Laboratories, Part 1
Tuesday, March 11, 2014
Kerstin Thurow
Silke Holzmüller-Laue
Bernd Göde
Generalized life science automation (LSA) includes all application areas of laboratory automation, i.e., health care, pharmaceutical development, chemistry, and biology. The connection of all ...
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The Scales of Scientific Justice in Translational Science: Data Reproducibility and Verifiable Science
Tuesday, March 04, 2014
Tristan Berto
The traditional “scales of justice” represent truth and fairness. For the scientific community, the balance is between big data (terabytes of data across numerous databases) on one scale and ...
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Improved Pipetting Technique: An “Out-of-the-Box” Solution to Reduce Manual Pipetting Errors
Monday, March 03, 2014
Tanya Knaide
Handheld air-displacement pipets are used in virtually every laboratory around the world. The technique and skills of individual pipet operators are critical to the accuracy of results of liquid ...
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Electronic Pipetting: The Call for Innovation
Thursday, February 27, 2014
Paula Heimler
Take a close look around most laboratories and you will find an old, barely used fixture. No one knows who ordered it or who it belongs to. It is yellowed, dusty, and top heavy, with a small keyboard ...
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Automated Colony Counting: A Critical Requirement for Advanced Cancer Research
Monday, February 10, 2014
Michael Rau
The colony counting method has long been recognized as the primary method for measuring the effects of radiation, chemotherapeutic drugs, and other agents on cell viability.
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Seeing Molecular Interactions of Large Complexes by Cryo Electron Microscopy at Atomic Resolution
Thursday, February 06, 2014
Laurie J. Wang
Z.H. Zhou
Suppose one has never seen an automobile and is asked to perform the simple task—while blindfolded—of adding gasoline to the car and checking its oil. A task like this is impossible to perform until ...
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Identification of Cancer Stem Cells Within Mixed Populations Using Live Cell RNA Detection
Thursday, January 09, 2014
Don Weldon
Steve McClellan
Despite the ubiquity of studies measuring mRNA and miRNA levels, many current techniques require cell lysis and are enormously disruptive to the cells being studied.
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Multiparameter Pluripotency Analysis Using Magnetic Bead Assays
Wednesday, August 28, 2013
Nikolai Stankiewicz
Thomas Siegl
Frederick Wiese
For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ...
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Detection of siRNA-Mediated Gene Modulation Using RNA Detection Probes
Monday, May 20, 2013
Don Weldon
Grace Johnston
To study the function of genes and biological pathways, researchers often use techniques such as RNA interference (RNAi) to modify gene expression. In RNAi experiments, it is important to determine ...
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Automated Cell Staining in Drug Discovery
Tuesday, April 09, 2013
Amy Yoder
Li Liu
Cell and molecular biology become more integral pieces of the modern drug discovery process on a seemingly daily basis. Monitoring the interaction of cells and internal cellular activity provides ...
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Automation in the Drug Discovery Process: Delivering Analytical Chemistry to Biologists and Beyond
Friday, March 08, 2013
Wendy Gaisford
Over the past decade, advances in genomic- and proteomic-based research techniques and instrumentation have resulted in major breakthroughs in the elucidation of the structure and function of disease ...
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Automated Liquid Handling Robots: Bridging the Gap Between Nanoliter Liquid Handling and Larger Volume Dispensing
Wednesday, March 06, 2013
Wendy Gaisford
The introduction of automated nanoliter volume liquid handling instrumentation has revolutionized work flows, reducing the tedium of manual pipetting and the potential for manual error. In addition, ...
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