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Title
Urinary Drug Testing: Small Changes for Big Improvements in Sensitivity
Tuesday, September 27, 2016
Jenny Cybulski
An oversight or mistake in drug testing can have dire consequences—a positive drug test can ruin the possibility of employment, turn an accident into a lawsuit, or cause a physician to discontinue ...
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2-D NMR Developments Improve Monoclonal Antibody Characterization
Monday, September 26, 2016
Kimberly L. Colson
Ten years ago, industry commentators noted the increasing importance of biologics, and monoclonal antibodies (mAbs), in particular.
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Cell Culture Advances Yield More Reliable Data for Cancer Research
Tuesday, July 26, 2016
James Lim
Cells stored with traditional culturing practices express different gene and protein profiles than their in vivo counterparts.
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Determination of Pain-Management Drugs in Human Urine Using “Flip-Flop” Chromatography and Time-of-Flight Mass Spectrometry
Monday, July 25, 2016
Ihuoma A. Igwilo
Nicholas T. Lappas
Ira S. Lurie
Methodology is presented for analysis of 13 pain-management drugs using reversed-phase and hydrophilic interaction chromatographic separations.
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Best Practices for CO
2
Incubator Maintenance
Friday, July 22, 2016
Mary Kay Bates
The use of long-established mutant lines in culture has shifted, and it is common to find researchers using more sensitive stem cells, primary cells and 3-D cultures in applications including vaccine...
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Special Protein Testing in the Clinical Laboratory: Overview of Available Assays
Friday, July 22, 2016
Robert J. Janetschek
The proteins found within the human machine are, quite literally, the building blocks of life: individual cells contain more than 5000 individual proteins.
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Improved Liquid Biopsies With Combined Digital PCR and Next-Generation Sequencing
Friday, February 19, 2016
George Karlin-Neumann
The discovery that circulating tumor DNA (ctDNA) can be found in the blood, urine and other bodily fluids of cancer patients has led to a new type of biopsy that bypasses surgery—liquid biopsy.
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A Review of Quetzal: A Linguistic Search Engine for Biomedical Literature
Wednesday, August 05, 2015
C. Tobin Magle
Quetzal is a biomedical literature search engine that uses simple strategies that contain few keywords combined with an extensive biomedical vocabulary and filter sets that mirror the discovery ...
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Reference Standards Address Technical Challenges in DNA Resequencing
Tuesday, August 04, 2015
Natalie A. LaFranzo
The extensive workflow required to analyze DNA samples using next-generation sequencing (NGS) leaves many opportunities for the introduction of variability.
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Liquid Biopsy Solutions for Noninvasive Molecular Profiling
Monday, June 22, 2015
Michael Schwartz
Liquid biopsy offers the potential to understand and treat cancer in ways never before possible. The concept is simple: collect tumor DNA after it enters the peripheral blood circulation and identify...
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Next-Generation Sequencing for Disease Biomarkers
Monday, December 15, 2014
Darren Lee
Next-generation sequencing (NGS) is beginning to provide powerful insights into genetic mutations and molecular networks underlying disease for a broad set of genes. NGS technologies promise to ...
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DNA Modification in Obese Persons: Detection and Estimation of Carboxymethyl-2’- Deoxyadenosine in Human Urine and DNA
Monday, September 01, 2014
Zeenat Ara Lila
Dawnn Flowers
Morgan Tubman-Jackson
Genetics, obesity, and lack of exercise play a vital role in the development of diabetes. Almost 80% of people with Type 2 diabetes are overweight.
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Micro RNA Profiling with a Multiplexed Assay
Monday, March 03, 2014
Mark Santos
From the discovery of new miRNAs to clarifying their biological roles and utility as biomarkers, micro RNA (miRNA)-based research is undergoing a period of change. Rigorous methods are therefore ...
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Comparative Analysis of Antinuclear Antibody and Antinuclear Antibody Spectrum
Friday, February 28, 2014
Cui Kong
Jianwei Zhou
Jinsong Sun
Aihua Shen
Qin Song
Xinke Chen
Li Li
The occurrence of autoimmune disease (AID) has increased 3–5% and has had a significant impact on human health. The detection of serum antinuclear antibody (ANA) is beginning to receive more attention...
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How Lab Informatics Technologies Help Meet Evolving Healthcare Needs
Wednesday, February 05, 2014
Shooki Grasiani
Don Koch
Randy Hice
As U.S. healthcare providers (HCPs) navigate a changing healthcare climate, diagnostic laboratories are playing an increasingly important role in helping them prevent medical errors, lower ...
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Automated On-Line Extraction and Analysis of Dried Blood Spot Cards
Wednesday, January 16, 2013
Lester Taylor
Na Pi Parra
Doug McIntyre
The use of dried blood spot cards for screening neonates for metabolic and genetic disorders was conceived and proposed almost 50 years ago. Since then, newborns in many countries have had their ...
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Vaccine Storage: Keeping Vaccines Safe When They Are In Highest Demand
Friday, January 04, 2013
Alex Esmon
Flu season is upon us and laboratories are doing their part to make sure vaccines are prepared and ready for distribution. One of the biggest problems faced by laboratories and clinics during flu ...
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