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The Helium Ion Microscope: Advances in Technology and Applications
Helium ion microscopy (HIM) offers the highest spatial resolution surface imaging of any scanning beam method, as well as extremely high surface sensitivity.
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Polymer Characterization Using Nanoscale Infrared Spectroscopy
Despite its widespread applications, infrared microspectroscopy has fundamental spatial resolution limits set by both the laws of optics and practical design constraints.
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Breaking the Sample Preparation Bottleneck With a New Approach to Microwave Digestion
Closed-vessel microwave digestion is widely recognized as the most effective technique for the digestion of samples for metals analysis by graphite furnace atomic absorption (GFAA), inductively ...
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Characterizing Nanometer-Scale Materials Using a Low-Angle Backscattered Electron Detector
Understanding the properties of new materials prior to fabrication can be challenging. Often, the structure of a material at very small scales is critical to its properties and performance.
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Ensuring the Purity of Acetonitrile During Quality Control Testing
Acetonitrile is a critical solvent for a number of important technologies. Its low viscosity and low chemical reactivity make it a popular choice as a mobile phase for liquid chromatography. It also ...
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Choosing Solvent Packaging to Increase Laboratory Efficiency and Quality While Reducing Waste Disposal Costs
Laboratory scientists have a finite number of work hours to accomplish their required research. The annual cost of a scientist and laboratory space for this research in today’s modern, instrument ...
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Ultrafast Flow Liquid Chromatography of Proteins
Ultrahigh-pressure liquid chromatography (UHPLC) has been applied successfully to separations of many small molecules, including peptides. Few studies have involved proteins, and these were narrowly ...
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Capillary UHPLC Coupled with MRM-MS for Quantitative, High-Sensitivity Bioanalysis
Over the past 20 years, liquid chromatography-multiple reaction monitoring-mass spectrometry (LC-MRM-MS) has become the primary tool for the bioanalysis of drugs and their metabolites in physiological...
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Implementing Natural Ventilation in the Offices of a Research Laboratory Building
The University of Washington (UW) is a leading public research and educational institution, with its largest of three campuses located in Seattle and adjacent to Lake Washington.
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Routine Implementation of Very-High-Pressure Liquid Chromatography in Pharmaceutical Development
High-pressure liquid chromatography is probably the most widely used analytical technique for characterizing drug substances and drug products in the pharmaceutical industry. It is widely employed ...
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The Importance of Planning and Coordination in Laboratory Design
The proven marks of modern laboratory design are sharing of resources, flexible use of space,and the ability to adapt to changing needs. In constructing various laboratories throughout the years, ...
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Transformation of a University Teaching Laboratory Through Innovative Solutions
This article describes the improvements made to a 4500-square-foot chemistry teaching laboratory within the University of Pennsylvania’s (Philadelphia) Chemistry ’58 building. The design was led by ...
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The Benefits of Renovated Laboratories
In an age of scarce financial resources and shortened deadlines, many laboratory-based organizations find that repurposing existing buildings is a less costly and faster way to bring facilities on-...
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Real-Time Detection of Central Nervous System Tissues on Bovine Carcasses Using Fluorescence Spectroscopy
Bovine spongiform encephalopathy (BSE) is a fatal, neurodegenerative transmissible spongiform encephalopathy (TSE) in cattle that is thought to be the cause of variant Creutzfeldt-Jakob disease (vCJD)...
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Mercury and Arsenic Speciation Analysis by IC-ICP-MS
Ion chromatography (IC) with conductivity detection has been used successfully to determine anionic and cationic substances as well as polar compounds such as amines and organic acids. However, in ...
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