Technical Article
Wayne P. Duncan, Patrick D. Perkins
Today, liquid chromatography-mass
spectrometry with electrospray ionization (LC-ESI-MS) is increasingly
being used as the technique of choice
for high-throughput pharmaceutical
analysis.
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Technical Article
Roger Guevremont, Beata Kolakowski
In the development of many LC-MS
methods, interferences are commonplace.
In an environment in which data
must stand up to rigorous scrutiny, such as in the pharmaceutical industry, selectivity of ...
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Application Note
Mark Springer
For drug developers, being able to see where a drug candidate is distributed in a targeted tissue helps them better assess the potential value of that compound as a pharmaceutical product.
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Technical Article
Changyu Quang, Geralyn Kocan, Daniel Tang, Douglas M. Fast, Steven M. Michael
Quantitative bioanalysis is the most
important application area of liquid
chromatography coupled with atmospheric
pressure ionization (API) tandem
mass spectrometric detection (LC-API-MS-MS) in ...
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Technical Article
Mahalakshmi Rudrabhatla, Jason S. Wood
The classical example of detrimental effects caused by bacteria, such as E. coli or Bacillus Anthracis, is through invasion of the host.
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Technical Article
Rosanne W. Slingsby, Rida Al-Horr, Christopher A. Pohl, Joung Hae Lee
There are times when an analytical challenge demands a solution that reaches beyond standard methodologies.
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Monday, February 18, 2008
Application Note
Suze M. van Leeuwen, BoonHua Tan, Dirk W. Grijpma, Jan Feijen, Uwe Karst
The basis for the physical properties of a (polymeric) material is found in its chemical composition.
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Monday, September 01, 2008
Technical Article
James A. Laramée, H. Dupont Durst, Theresa R. Connell, J. Michael Nilles
Analysis of low-volatility, condensed- phase chemicals on surfaces has been an extremely difficult and long-standing objective in environmental monitoring.
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Technical Article
Heidi Fleischer, Dirk Gördes, Kerstin Thurow
In the past decades, high-throughput screening (HTS) applications have been established in many fields of drug development. Thus, suitable qualitative and quantitative analytical methods have become ...
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Technical Article
Ying Jiang Xu, Xiu Hui Tian, Xiu Zhen Zhang, Xiang Hong Gong, Shi Juan Zhang, Hui Hui Liu, Li Min Zhang
Hormones, such as androgens (AS), estrogens (ES), and progestogens (PS), play an important role in organisms. AS, the main male sex steroids,which are the critical factors responsible
for the ...
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Technical Article
Zeenat Ara Lila, Paulette Allen, Tameka Greenwood, Kadeem Bartley, Rafida Idris, Mahtabuddin Ahmed
Glycoxidative modification of proteins involving free radical intermediates and reactive carbohydrates leads to complications in diabetes, atherosclerosis, and Alzheimer’s disease.
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Technical Article
Robert L. Stevenson
In an opening plenary, Prof. Barry
Karger of the Barnett Institute of
Chemical and Biological Analysis
concisely defined analytical chemistry as “The science of generating relevant information by ...
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Thursday, September 01, 2011
Technical Article
Heidi Fleischer, Kerstin Thurow
The enantiomeric composition of proline is commonly determined using conventional analytical methods such as HPLC, GC,
and CE.
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Tuesday, January 10, 2012
Application Note
Robert L. Stevenson
Sample preparation is the most
critical part of a chromatographic
assay.
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Technical Article
Jeffrey M. Perkel
This past March, some 15,754 people
from 90 countries descended on Orlando, Florida, for the annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Pittcon®).
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Technical Article
Zeenat Ara Lila, Kamika Manzano, Gabrielle Jenkins, Tatreka M. Polite, Miranda Williamson, Rafida Idris, Mahtabuddin Ahmed
The involvement of proteins in glycoxidative and lipoperoxidation reactions leads to conditions such as cataracts in lenses, atherosclerosis, and other age-related diseases.
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Wednesday, December 12, 2012
Technical Article
Robert L. Stevenson
Innovation is a respected attribute that many companies claim as a core business strategy. The pace of innovation spurred by technology such as smartphones, tablet PCs, and high-speed internet has ...
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Wednesday, January 16, 2013
Application Note
Lester Taylor, Na Pi Parra, Doug McIntyre
The use of dried blood spot cards for screening neonates for metabolic and genetic disorders was
conceived and proposed almost 50 years ago. Since then, newborns in many countries have had their ...
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Thursday, February 14, 2013
Technical Article
Lynn Vanatta
In modern scientific laboratories, the electrospray mass spectrometer is being used extensively. The instrument is highly specific and for many applications is quite sensitive.
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