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  • Impact of New Pipetting Techniques on Safety in the Laboratory

    Monday, September 02, 2013
    Application Note
    Bobby Chavli Annette Summers Mary Napier
    According to the Occupational Safety and Health Administration (OSHA), on average, it takes between 18 and 36 months to develop and implement a new regulation, trailing the pace of science. As a ... read more
  • DNA in Forensics

    Wednesday, August 28, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The proliferation of forensic DNA testing and databases by state and local jurisdictions was recently reported by Joseph Goldstein in The New York Times. For years, the FBI’s combined indexing system ... read more
  • Multiparameter Pluripotency Analysis Using Magnetic Bead Assays

    Wednesday, August 28, 2013
    Application Note
    Nikolai Stankiewicz Thomas Siegl Frederick Wiese
    For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ... read more
  • High-Resolution Separation of Nucleic Acid Fragments

    Wednesday, August 07, 2013
    Application Note
    Carola Schade
    The invention of the polymerase chain reaction (PCR) in the early 1980s revolutionized molecular biology and molecular medicine. Since then, PCR has developed into a widely used technique for ... read more
  • A Capillary Gel Electrophoresis Fluorescence System for Antibody–Antigen Interactions

    Wednesday, August 07, 2013
    Application Note
    Shou-Kuan Tsai Ming-Jhy Hseu Varoujan D. Amirkhanian
    Since its inception more than 20 years ago, slab gel-based electrophoresis technology has been used routinely for the analysis of biomolecules (i.e., DNA, proteins, and carbohydrates). However, use of... read more
  • Innovation Thrives at the American Society for Mass Spectrometry 2013

    Tuesday, August 06, 2013
    Technical Article
    Paul O Danis
    When J.J. Thomson, the father of mass spectrometry, published his seminal book, Rays of Positive Electricity, 100 years ago, he could not have imagined the vast array of applications that would be ... read more
  • Translational Medicine and the ’Omics Electronic Lab Notebooks

    Tuesday, August 06, 2013
    Technical Article
    Chris Molloy
    Translational medicine research (TransMed) is a new environment in which groups of stakeholders come together to review increasingly complex data with the goals of improving outcomes, getting more ... read more
  • The Role of Synthetic DNA in Big DNA and Genetics Research

    Friday, August 02, 2013
    Technical Article
    Dan Gibson Hans Packer
    Synthetic biology is defined as the de novo design and construction of biological devices and systems, and as such is heavily reliant on the use of synthetic DNA. The size and sequence of potential ... read more
  • Measurement of IL-6 RNA Levels in Live Cells

    Wednesday, July 10, 2013
    Application Note
    Shobana Vaidyanathan
    Infections and tissue damage lead to acute inflammatory responses, orchestrated by the release of cytokines from macrophages and mast cells, as well as endothelium and tumor cells. Tumor necrosis ... read more
  • High-Throughput Screening of Multiple Protein Complexes

    Thursday, July 04, 2013
    Application Note
    Imre Berger Maxime Chaillet Frederic Garzoni Sinyee Yau-Rose Barney Zoro
    Key protein complexes are fundamental to a wide range of cellular processes and key metabolic pathways within the body. Their dysfunction is associated with a range of disease pathologies such as ... read more
  • 37th International Symposium on Capillary Chromatography

    Tuesday, July 02, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    Capillary chromatography is in the mainstream of the technical evolution of chromatography, driven primarily by improvements in column technology that generally precede the development of the ... read more
  • Product Intelligence: Thermal Cyclers: Behind the Technology

    Friday, June 28, 2013
    Technical Article
    Caitlin Smith
    Also referred to as thermocyclers, DNA amplifiers, or PCR machines, thermal cyclers are a vital part of the molecular biology laboratory. Many choices of thermal cycler are available, and this article... read more
  • Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays

    Friday, June 07, 2013
    Application Note
    Amedeo Cappione Masaharu Mabuchi David Briggs Timothy Nadler
    Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-... read more
  • Detection of siRNA-Mediated Gene Modulation Using RNA Detection Probes

    Monday, May 20, 2013
    Application Note
    Don Weldon Grace Johnston
    To study the function of genes and biological pathways, researchers often use techniques such as RNA interference (RNAi) to modify gene expression. In RNAi experiments, it is important to determine ... read more
  • Pittcon 2013®: Developments in Liquid Chromatography

    Monday, May 13, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The first commercial liquid chromatograph was probably an amino acid analyzer. These ion exchange chromatographs were so specialized that they had almost no impact on chemical analysis outside of ... read more
  • Advances in Mass Spectrometry at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Brian Musselman
    This has been a busy year for mass spectrometry companies and with the Triennial International Conference on Mass Spectrometry occurring last fall. This year at Pittcon®, several new high-end mass ... read more
  • Putting the “More” in Morphology: Part 2

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Part 1 of this article discussed the impact of multiplexing morphological methods, multiparametric techniques, and supervised machine-learning to answer the question "what" is there, as well as "where... read more
  • Analysis of Cathinones in Bath Salts by Direct Sample Analysis TOF/MS

    Thursday, February 14, 2013
    Application Note
    Noelle M. Elliott Avinash Dalmia Carl Schwarz Amanda M. Leffler Frank Dorman
    Synthetic cathinones are gaining popularity as drugs of abuse and are often sold in bath salts. Currently, there is no standard method to quickly screen and confirm cathinones in bath salts. read more
  • Analyzing Volatile Organic Chemicals in Food: Emerging Trends and Recent Examples

    Thursday, February 14, 2013
    Technical Article
    David Barden
    The detection of volatile organic compounds (VOCs) is important for a variety of reasons, many of which stem either from the need to ensure that damaging chemicals are controlled or eliminated, or the... read more
  • New Technology for the Characterization of Nanometals

    Friday, November 23, 2012
    Technical Article
    Robert L. Stevenson, Ph.D.
    Characterization of nanoparticles is a complex challenge. Key properties include concentration, particle size, particle size distribution, surface charge, surface area, shape, structure, composition, ... read more
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