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  • Transitioning From HPLC to UHPLC of Proteins

    Wednesday, March 09, 2016
    Application Note
    Robert L. Stevenson, Ph.D.
    Since the introduction of ACQUITY UPLC (Ultra Performance Liquid Chromatography) by Waters (Milford, Mass.) over a decade ago, there has been increased interest in the effects of high pressure on ... read more

  • A Simplified Approach to Bioanalytical Sample Preparation

    Wednesday, April 08, 2015
    Application Note
    Erica Pike
    The complexity of biological samples can pose challenges to downstream analysis in the pharmaceutical industry. Bioanalytical and drug metabolism and pharmacokinetics (DMPK) groups often work with ... read more

  • Sample Processing at Pittcon® 2014

    Tuesday, May 06, 2014
    Application Note
    Robert L. Stevenson, Ph.D.
    The tenfold increase in speed for the analytics (GC, HPLC, and SFC [supercritical fluid chromatography], all with MS) over the last decade has shifted the choke point in many workflows from analytics ... read more

  • Sample Prep for LC, GC, and SFC at Pittcon® 2013

    Friday, May 10, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    At Pittcon® 2013, sample prep stood out as a major focus, perhaps because of the few advances in chromatography instrumentation. In addition, some sample preparation is spilling over into other ... read more

  • New Instrumentation and Applications at HPLC 2012

    Friday, August 10, 2012
    Technical Article
    Robert L. Stevenson, Ph.D.
    A marketplace is usually dynamic, with a cross-current of disparate interests meeting to find mutual satisfaction. read more

  • Statistics in Analytical Chemistry: Part 22—Lack-of-Fit Details

    Thursday, June 01, 2006
    Technical Article
    David Coleman Lynn Vanatta
    Because of popular demand from readers, this installment will discuss the principles and calculations that underlie the lack-of-fit (LOF) test. read more
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