Dr. Matthew Levy, Director of the Biological Imaging Core at University of Norte Dame, describes the variety of clinical and pre-clinical Bruker multi modal imaging systems at their core facility. The Albira system includes X-ray CT, PET and SPECT used for applications such as measuring adipose tissue content or lung tissue burden. The In-Vivo Xtreme system consists of high resolution X-ray, fluorescence, luminescence, and radio-isotopic imaging. The unique ICON MR system is used for applications such as stroke imaging and tumor imaging. Clinical imaging strategies will continue to grow and benefit the medical imaging community.