The NEPHELOstar Plus, is a laser-based microplate nephelometer for the measurement of light scattering for solubility and aggregation measurements. This light scattering measurement instrument works with microplates up to 384-wells and can detect insoluble particles in a solution, which is useful for drug solubility, protein aggregation, or cell growth measurements. New features include a stable laser, CFR-compatibility, and an atmospheric control unit. The NEPHELOstar Plus Nephelometer enables higher sample throughput for light scattering applications, such as compound solubility, microbial growth kinetic monitoring, or protein aggregation.