FEI Announces New Tecnai Arctica TEM for Structural Biology Research

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The Tecnai Arctica’s lower overall cost-of-ownership makes advanced structural analysis available to a broader range of facilities and budgets.

Hillsboro, Ore./January 30, 2013— FEI (NASDAQ: FEIC) today announced the availability of its Tecnai Arctica™ transmission electron microscope (TEM) for structural biology research. The Tecnai Arctica incorporates sophisticated automation, pioneered on FEI’s flagship Titan Krios™ TEM, to elucidate the three-dimensional (3D) structure of biological macromolecules and molecular complexes. With the addition of the Tecnai Arctica, FEI now offers a portfolio of structural biology workflows to accommodate a broad range of facilities and budgets.

The Tecnai Arctica is specifically designed for structural biologists who are focused on increasing productivity and reducing cost-of-ownership. The system’s high throughput and easy-to-use, highly-automated workflow, combined with its lower acquisition cost, minimize the overall cost of analysis per structure.

“Most proteins act together with other proteins in multi-molecular complexes, and understanding relationships between structure and function within these complexes is the key to understanding all living systems,” said Peter Fruhstorfer, vice president of FEI’s Life Sciences Business. “Traditional tools, such as X-ray diffraction and nuclear magnetic resonance, are limited to certain classes of molecules. Cryo TEMs, like our Titan Krios, and now the Tecnai Arctica, can look at virtually any molecule or complex of molecules in a native, fully-hydrated state. We believe that the role of cryo TEM in structural biology analysis, which has expanded dramatically in recent years, should continue to grow at an accelerating rate as instruments like the Tecnai Arctica TEM make the technology accessible to a wider range of researchers.”

Much of the recent progress in cryo TEM-based structural analysis uses a technique known as single particle analysis (SPA), which combines images of tens or hundreds of thousands of nominally identical particles to derive a high resolution, low noise, 3D model. The particles are first rapidly frozen in physiological solution to preserve their native structure. The Tecnai Arctica is part of a tightly-integrated, start-to-finish workflow, comprising cryo-sample preparation, data acquisition and analysis and final visualization, which greatly enhances the speed and efficiency of analysis. Its cryo-sample autoloader, combined with automated target identification and low dose imaging, enable unattended acquisition of large SPA data sets that are practically impossible to acquire with manual methods. Its streamlined user interface and extensive automation of routine operations and set up procedures significantly lower the threshold for operator expertise.

“FEI’s Tecnai TEMs are a well-proven platform with over 1,000 systems deployed globally in life sciences, materials science, nanotechnology, semiconductor and data storage applications. While the Tecnai is one of our most widely-used TEM platform, The Titan Krios remains the leading TEM for structural biologists who require the highest resolution over the broadest range of samples for advanced analytical techniques, such as electron tomography,” added Fruhstorfer.

For more information about the Tecnai Arctica TEM, please visit: www.fei.com/tecnai_arctica or contact your local sales representative.

About FEI

FEI (Nasdaq: FEIC) is a leading supplier of scientific instruments for nanoscale applications and solutions for industry and science. With more than 60 years of technological innovation and leadership, FEI has set the performance standard in transmission electron microscopes (TEM), scanning electron microscopes (SEM) and DualBeams™, which combine a SEM with a focused ion beam (FIB). FEI has over 2,300 employees and sales and service operations in more than 50 countries around the world. More information can be found at: www.fei.com.

FEI Safe Harbor Statement

This news release contains forward-looking statements that include statements regarding the performance capabilities and benefits of FEI’s Tecnai Arctica TEM. Factors that could affect these forward-looking statements include but are not limited to failure of the product or technology to perform as expected and achieve anticipated results or cost savings, unexpected technology problems and challenges, changes to the technology, the inability of FEI, its suppliers or project partners to make the technological advances required for the technology to achieve anticipated results, the inability of customers to develop and deploy the expected new applications and our ability to manufacture, ship and deliver the tools or software as expected. Please also refer to our Form 10-K, Forms 10-Q, Forms 8-K and other filings with the U.S. Securities and Exchange Commission for additional information on these factors and other factors that could cause actual results to differ materially from the forward-looking statements. FEI assumes no duty to update forward-looking statements.

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