Crown Bioscience, Inc. and Horizon Discovery, Ltd. to Showcase X-MAN Cell Lines for In Vivo and In Vitro Drug Discovery Model Validation at EORTC-NCI-AACR Symposium

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Santa Clara, CA and Cambridge, UK (November 06 2012) – Crown Bioscience, Inc., a leading global drug discovery and development service company, and Horizon Discovery Ltd., a leading provider of research tools to support the development of personalized medicines, will highlight the availability of X-MAN™ cell lines for in vitro and in vivo drug discovery model validation at the 24th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Nov 6-9, 2012.

High-quality human disease models are crucial for generating 'first-in-class' patient-relevant targets and facilitating the development of novel oncology targets and early-stage drug discovery programs within the pharmaceutical industry. The new in vivo X-MAN (X-Gene Mutant And Normal) models will be made available to customers by Crown Bioscience via a new service offering whilst Horizon will provide access to a broad range of in vitro services based around its inventory of; >450 X-MAN cell lines, >50 phenotypic cell-based assays and its SyntheTx™ drug/RNAi screening platform.

Leveraging their unique drug discovery and translational research platforms, Crown Bioscience and Horizon Discovery help develop the best drug candidates with high confidence for clinical development, reducing drug attrition and development cost. Crown Bioscience and Horizon Discovery are ideally placed to help bring to the clinic lead molecules based upon highly validated and novel drug models. The in vitro and in vivo cell lines are available to clients who want to help validate new models and become early adopters with full access to new models at the earliest possible phase.

“Crown Bioscience aspires to become the innovation engine for the global biotech and pharmaceutical industry. We are guided by our responsibility to clients and a desire to make a major positive impact on human life worldwide. We are constantly pioneering new paths and finding new answers to meet the urgent needs of our customers’ waging war against cancer,” said Jean-Pierre Wery, President of Crown Bioscience. “The novel in vivo models we are developing based on the X-MANTM cell lines offer new opportunities for clients to collaborate with us at an early stage and validate the models based on their needs, This will allow greater insights and better means to evaluate the therapeutic efficacy of compounds and their impact on key physiological functions.”

“Horizon Discovery uses its highly efficient and proprietary gene-engineering platform technology, GENESIS™ to precisely engineer X-MAN human disease models that harbor the key genetic features that drive a patient’s disease” commented Darrin Disley, CEO of Horizon Discovery. “We are delighted to provide Crown Bioscience with our unique range of X-MAN cell lines, so that Crown can develop and provide our clients with a suite of in vivo models that complements our extensive range of in vitro services.”

The new in vivo models demonstrate Crown Bioscience’s commitment to continuing to invest in and expand its portfolio of models and to work collaboratively with partners and clients to accurately and robustly evaluate the efficacy of new therapeutic agents. The in vivo models are designed to help clients address their key needs and challenges by providing cutting-edge clinically relevant models that are ready to run. Crown Bioscience’s comprehensive services for drug development, from target to pre-IND, have accelerated confident Go/No Go decisions during early stage drug discovery and ensured robust pre-clinical candidate selection.

To learn more please visit Crown Bioscience at booth #C3 and Horizon Discovery at booth #A4 at the 24th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Nov 6-9, 2012.

Alternatively please email pr@mail.crownbio.com, call 001 408 986 0103 or visit www.crownbio.com (for Crown Bioscience Inc) or xman@horizondiscovery.com, call 0044 1223 655 580 or visit www.horizondiscovery.com (for Horizon Discovery Ltd)

About Crown Bioscience Inc.

Founded in 2006, Crown Bioscience is a premier drug discovery and development service company providing cutting-edge translational platforms and cost effective drug discovery solutions for its biotech and pharmaceutical partners in dedicated therapeutic areas: Oncology and Metabolic Disease. Our proprietary HuPrime®, HuKemia®, HuBase™, HuMark™, HuTrials™ and HuSignature™ platforms enable unique lead optimization and translational strategies to deliver superior clinical candidates. Headquartered in Santa Clara California, Crown Bioscience has operations in China (Beijing and Jiangsu Taicang) and the USA (NC) with business offices in the Boston, Princeton, RTP, Phoenix, Milan and Shanghai. For more information, please visit http://www.crownbio.com.

About Horizon Discovery Ltd.

Horizon Discovery Limited (Horizon) is a leading provider of research tools to support translational genomics research and the development of personalized medicines. Using GENESIS™, the Company’s proprietary rAAV gene-editing technology, Horizon is able to alter any endogenous gene sequence of a human or mammalian cell-line quickly, reliably and without introducing unwanted and confounding genotypes and/or phenotypes.

Horizon has applied GENESIS™ to create over 450 X-MAN™ cell lines, the world’s first source of genetically-defined and patient-relevant human cell lines, accurately modeling the disease-causing mutations found in cancer patients. These ‘patients-in-a-test-tube’ are being used by academic and industry leaders to identify the effect of individual or compound genetic mutations on drug activity, patient responsiveness, and resistance, leading to the successful prediction of which patient sub-groups will respond to currently-available and future drug treatments. This enables the design of shorter, more focused, and less expensive clinical trials, ultimately providing the tools to identify the ‘right drugs’ for the ‘right patients’ based upon the unique genetic mutations that define their disease.

In addition to the X-MAN™ cell lines, Horizon provides GENESIS™ and X-MAN™ derived products and services, with industrial application in: bio-pharmaceutical process optimization; clinical diagnostic development; drug discovery & development; and the provision of reference standards for genomic-based clinical research platforms.

GENESIS, X-MAN and SyntheTx are registered trademarks of Horizon Discovery Limited. For more information, please visit http://www.horizondiscovery.com.

Contacts

For Crown Bioscience
Sarah Morley
The Scott Partnership
Tel: + 44 1477 539 539
Fax: +44 1477 539 540
E-mail: crown@scottpr.com

For Horizon Discovery
Katie Odgaard
Zyme Communications
Tel: +44 7787 502 947
E-mail: katie.odgaard@zymecommunications.com

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